|Reference : Application of MRI for improved local control in complex radiotherapy of cervical cancer|
|Scientific journals : Article|
|Human health sciences : Oncology|
|Application of MRI for improved local control in complex radiotherapy of cervical cancer|
|Janaki, Hadjiev [ > > ]|
|Zsolt, Cselik [ > > ]|
|Péter Bogner [ > > ]|
|Árpád, Kovács [ > > ]|
|LAKOSI, Ferenc [Centre Hospitalier Universitaire de Liège - CHU > > Radiothérapie >]|
|Gyula, Kotek [ > > ]|
|Imre, Repa [ > > ]|
|Archive of Oncology|
|Institute of Oncology Sremska Kamenica|
|[en] Uterine Cervical Neoplasms; ; ; ; , ; Interventional ; Radiology ; Dosage ; Radiotherapy ; Brachytherapy ; Magnetic Resonance Imaging|
|[en] Background: The aim of this study was to analyze the use of magnetic resonance imaging (MRI) as a
modern medical imaging technique in radiotherapy with special emphasis on the integration of MRI and
a novel technique in brachytherapy to optimize treatment outcome in cervical cancer.
Methods: In addition to the CT based shrinking volume conformal teletherapy in 31 patients with locally
advanced cervical cancer, MRI examination with a special adjustable applicator at the treatment site was
performed for the brachytherapy planning. To avoid excessive doses to the healthy structures during
complex cervical radiotherapy isodose curves were calculated upon the information of the MR image
and dose distribution was evaluated.
Results: The consecutive application of CT and MRI limited the possibility for overdosage of the critical
organs and undertreatment of the advanced tumor spread in all cases. The overall response rate for
the complex treatment was 74.2% with complete regression in 25.8% of the cases. Based on the exact
information of the three dimensional digital data radiation doses could be optimized without increasing
the possibility of acute complications rate.
Conclusion: The introduction of 3D treatment planning for teletherapy pelvic and boost irradiation of
cervical carcinoma as well as for the brachytherapy part of the complex treatment is to be recommended.
|Researchers ; Professionals|
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