Reference : Tocol modified glycol chitosan for the oral delivery of poorly soluble drugs
Scientific journals : Article
Engineering, computing & technology : Materials science & engineering
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/110902
Tocol modified glycol chitosan for the oral delivery of poorly soluble drugs
English
Duhem, Nicolas [Université catholique de Louvain (UCL), Brussels > Louvain Drug Research Institute (LDRI) > Pharmaceutics and Drug Delivery > >]
Rolland, Julien [Université catholique de Louvain (UCL) > Institute of Condensed Matter and Nanosciences > Bio and Soft Matter > >]
Riva, Raphaël [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Guillet, Pierre [Université catholique de Louvain (UCL) > Institute of Condensed Matter and Nanosciences > Bio and Soft Matter > >]
Schumers, Jean-Marc [Université catholique de Louvain (UCL) > Institute of Condensed Matter and Nanosciences > Bio and Soft Matter > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Gohy, Jean-François [Université catholique de Louvain (UCL) > Institute of Condensed Matter and Nanosciences > Bio and Soft Matter > >]
Préat, Véronique [Université catholique de Louvain (UCL), Brussels > Louvain Drug Research Institute (LDRI) > Pharmaceutics and Drug Delivery > >]
28-Feb-2012
International Journal of Pharmaceutics
Elsevier Science
423
2
452-460
Yes (verified by ORBi)
International
0378-5173
Amsterdam
The Netherlands
[en] nanomedicine ; chitosan
[en] The aim of this study was to develop tocol derivatives of chitosan able (i) to self-assemble in the gastrointestinal tract and (ii) to enhance the solubility of poorly soluble drugs. Among the derivatives synthesized, tocopherol succinate glycol chitosan (GC-TOS) conjugates spontaneously formed micelles in aqueous solution with a critical micelle concentration of 2 μg mL−1. AFM and TEM analysis showed that spherical micelles were formed. The GC-TOS increased water solubility of 2 model class II drugs. GC-TOS loading efficiency was 2.4% (w/w) for ketoconazole and 0.14% (w/w) for itraconazole, respectively. GC-TOS was non-cytotoxic at concentrations up to 10 mg mL−1. A 3.4-fold increase of the apparent permeation coefficient of ketoconazole across a Caco-2 cell monolayer was demonstrated. Tocol polymer conjugates may be promising vehicles for the oral delivery of poorly soluble drugs.
Center for Education and Research on Macromolecules (CERM)
The Walloon Region in the frame of the Winnomat 2 CHITOPOL program
Researchers
http://hdl.handle.net/2268/110902
10.1016/j.ijpharm.2011.12.010
http://pdn.sciencedirect.com/science?_ob=MiamiImageURL&_cid=271189&_user=532038&_pii=S0378517311011367&_check=y&_origin=browse&_zone=rslt_list_item&_coverDate=2012-02-28&wchp=dGLbVlS-zSkzS&md5=985d84491c98eb1f7abe7a5a0f9bd7a6/1-s2.0-S0378517311011367-main.pdf

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