Reference : Comedolysis by a lipohydroxyacid formulation in acne-prone subjects.
Scientific journals : Article
Human health sciences : Dermatology
http://hdl.handle.net/2268/11088
Comedolysis by a lipohydroxyacid formulation in acne-prone subjects.
English
Uhoda, Emmanuelle [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Pierard, Claudine [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Pierard, Gérald mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
2003
European Journal of Dermatology
John Libbey Eurotext
13
1
65-8
Yes (verified by ORBi)
1167-1122
Montrouge
France
[en] Acne Vulgaris/etiology/pathology/prevention & control ; Adult ; Female ; Humans ; Salicylic Acids/therapeutic use ; Skin/pathology ; Sunlight/adverse effects
[en] Post-summertime exacerbation of acne is not a rare event. This study was conducted to assess the preventive effect of a proprietary formulation containing 2-hydroxy-5-octanoyl benzoic acid on this environmental related disease. This compound is commonly called beta-lipohydroxyacid (LHA). Among a randomized group of 14 acne-prone women, 12 who developed cornified follicular plugs the end of summertime were treated by the LHA formulation twice daily for 2 weeks. Ten of 14 other women who presented the same skin condition remained untreated as controls. The comedolytic effect was assessed using non-invasive ultraviolet-light video recording combined with computerized image analysis. The cornified follicular plugs were progressively cleared in 10/12 LHA-treated women and in 3/10 untreated volunteers. Analytical assessments showed a significant decrease in both the number and total size of microcomedones in the LHA-treated women. By contrast, no quantitative change was disclosed in the untreated group. It is concluded that the tested LHA formulation exerts comedolytic properties that might help in preventing post-summertime acne exacerbations.
http://hdl.handle.net/2268/11088

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