Reference : Common variants at five new loci associated with early-onset inflammatory bowel disease.
Scientific journals : Article
Human health sciences : Gastroenterology & hepatology
http://hdl.handle.net/2268/11079
Common variants at five new loci associated with early-onset inflammatory bowel disease.
English
Imielinski, Marcin [> > > >]
Baldassano, Robert N [> > > >]
Griffiths, Anne [> > > >]
Russell, Richard K [> > > >]
Annese, Vito [> > > >]
Dubinsky, Marla [> > > >]
Kugathasan, Subra [> > > >]
Bradfield, Jonathan P [> > > >]
Walters, Thomas D [> > > >]
Sleiman, Patrick [> > > >]
Kim, Cecilia E [> > > >]
Muise, Aleixo [> > > >]
Wang, Kai [> > > >]
Glessner, Joseph T [> > > >]
Saeed, Shehzad [> > > >]
Zhang, Haitao [> > > >]
Frackelton, Edward C [> > > >]
Hou, Cuiping [> > > >]
Flory, James H [> > > >]
Otieno, George [> > > >]
Chiavacci, Rosetta M [> > > >]
Grundmeier, Robert [> > > >]
Castro, Massimo [> > > >]
Latiano, Anna [> > > >]
Dallapiccola, Bruno [> > > >]
Stempak, Joanne [> > > >]
Abrams, Debra J [> > > >]
Taylor, Kent [> > > >]
McGovern, Dermot [> > > >]
Heyman, Melvin B [> > > >]
Ferry, George D [> > > >]
Kirschner, Barbara [> > > >]
Lee, Jessica [> > > >]
Essers, Jonah [> > > >]
Grand, Richard [> > > >]
Stephens, Michael [> > > >]
Levine, Arie [> > > >]
Piccoli, David [> > > >]
Van Limbergen, Johan [> > > >]
Cucchiara, Salvatore [> > > >]
Monos, Dimitri S [> > > >]
Guthery, Stephen L [> > > >]
Denson, Lee [> > > >]
Wilson, David C [> > > >]
Grant, Struan F A [> > > >]
Daly, Mark [> > > >]
Silverberg, Mark S [> > > >]
Satsangi, Jack [> > > >]
Hakonarson, Hakon [> > > >]
Silber, Gary [> > > >]
Wrobel, Iwona [> > > >]
Quiros, Antonio [> > > >]
Barrett, Jeffrey C [> > > >]
Hansoul, Sarah [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Nicolae, Dan L [> > > >]
Cho, Judy H [> > > >]
Duerr, Richard H [> > > >]
Rioux, John D [> > > >]
Brant, Steven R [> > > >]
Barmada, M Michael [> > > >]
Bitton, Alain [> > > >]
Dassopoulos, Themistocles [> > > >]
Datta, Lisa Wu [> > > >]
Green, Todd [> > > >]
Kistner, Emily O [> > > >]
Murtha, Michael T [> > > >]
Regueiro, Miguel D [> > > >]
Rotter, Jerome I [> > > >]
Schumm, L Philip [> > > >]
Steinhart, A Hillary [> > > >]
Targan, Stephan R [> > > >]
Xavier, Ramnik J [> > > >]
Libioulle, Cécile mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
Sandor, Cynthia mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Lathrop, Mark [> > > >]
Belaiche, Jacques mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gastro-Entérologie-Hépatologie >]
Dewit, Olivier [> > > >]
Gut, Ivo [> > > >]
Heath, Simon [> > > >]
Laukens, Debby [> > > >]
Mni, Myriam mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Rutgeerts, Paul [> > > >]
Van Gossum, Andre [> > > >]
Zelenika, Diana [> > > >]
Franchimont, Denis [> > > >]
Hugot, J. P. [> > > >]
Devos, Martine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Centre d'oncologie >]
Vermeire, Severine [> > > >]
Louis, Edouard mailto [Université de Liège - ULg > Département des sciences cliniques > Hépato-gastroentérologie - Relations académiques et scientifiques (Médecine) >]
Cardon, Lon R [> > > >]
Anderson, Carl A [> > > >]
Drummond, Hazel [> > > >]
Nimmo, Elaine [> > > >]
Ahmad, Tariq [> > > >]
Prescott, Natalie J [> > > >]
Onnie, Clive M [> > > >]
Fisher, Sheila A [> > > >]
Marchini, Jonathan [> > > >]
Ghori, Jilur [> > > >]
Bumpstead, Suzannah [> > > >]
Gwillam, Rhian [> > > >]
Tremelling, Mark [> > > >]
Deloukas, Panos [> > > >]
Mansfield, John [> > > >]
Jewell, Derek [> > > >]
Mathew, Christopher G [> > > >]
Parkes, Miles [> > > >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
2009
Nature Genetics
Nature Publishing Group
41
12
1335-40
Yes (verified by ORBi)
International
1061-4036
1546-1718
New York
NY
[en] The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD.
Researchers ; Professionals
http://hdl.handle.net/2268/11079
10.1038/ng.489

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