Reference : Is brain estradiol a hormone or a neurotransmitter?
Scientific journals : Letter to the editor
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/11040
Is brain estradiol a hormone or a neurotransmitter?
English
Balthazart, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
Ball, G. F. [> > > >]
May-2006
Trends in Neurosciences
Elsevier Science London
29
5
241-249
Yes (verified by ORBi)
International
0166-2236
London
[en] Appetitive Behavior/physiology ; Appetitive Behavior/physiology ; Aromatase/metabolism ; Brain/enzymology/physiology ; Estradiol/physiology ; Female ; Hormones/physiology ; Humans ; Intracellular Fluid/metabolism ; Male ; Neurotransmitter Agents/physiology ; Sexual Behavior, Animal/physiology ; Signal Transduction/physiology
[en] Mounting evidence indicates that, besides their well-known hormonal mode of action at the genetic level, estrogens such as 17 beta-estradiol also influence brain function by direct effects on neuronal membranes. Experimentally induced rapid changes in estradiol bioavailability in the brain have been shown to alter the expression of male sexual behavior significantly within minutes - probably too quickly to be accounted for by conventional genetic mechanisms. In parallel, recent studies indicate that aromatase, the enzyme that converts testosterone to estradiol in the brain, is expressed in presynaptic terminals and modulated within minutes by Ca2+-dependent phosphorylation. In this article, we develop the hypothesis that brain estrogens display many, if not all, functional characteristics of neuromodulators or even neurotransmitters.
http://hdl.handle.net/2268/11040
10.1016/j.tins.2006.03.004

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