Reference : The microtubule-associated protein doublecortin is broadly expressed in the telenceph...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/11030
The microtubule-associated protein doublecortin is broadly expressed in the telencephalon of adult canaries
English
Boseret, Géraldine mailto [Université de Liège - ULg > > Interface Entreprises-Université >]
Ball, G. F. [> > > >]
Balthazart, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
May-2007
Journal of Chemical Neuroanatomy
Elsevier Science Bv
33
3
140-154
Yes (verified by ORBi)
International
0891-0618
Amsterdam
[en] doublecortin ; HVC ; songbirds ; neuroplasticity
[en] The protein doublecortin (DCX) is expressed in post-mitotic migrating and differentiating neurons in the developing vertebrate brain and, as a part of the microtubule machinery, is required for neuronal migration. DCX expression is generally maximal during embryonic and early post-natal life but decreases markedly and almost disappears in older animals in parallel with the major decrease or cessation of neurogenesis. In several seasonally breeding songbird species such as canaries, the volume of several song control nuclei in the brain varies seasonally such that the largest nuclei are observed in the late spring and early summer. This variation is based on changes in cell size, dendritic branching, and, in nucleus HVC, on the incorporation of neurons newly born in adulthood. Because songbirds maintain an active neurogenesis and neuronal incorporation in their telencephalon throughout their lives, we investigated here the distribution of DCX-immunoreactive (ir) structures in the brain of adult male canaries. Densely stained DCX-ir cells were found exclusively in parts of the telencephalon that are known to incorporate new neurons in adulthood, in particular the nidopallium. Within this brain region, the boundaries of the song control nucleus HVC could be clearly distinguished from surrounding structures by a higher density of DCX-ir structures. In most telencephalic areas, about two thirds of these cells displayed a uni- or bipolar fusiform morphology suggesting they were migrating neurons. The rest of the DCX-ir cells in the telencephalon were larger and had a round multipolar morphology. No such staining was found in the rest of the brain. The broad expression of DCX specifically in adult brain structures that exhibit the characteristic of active incorporation of new neurons suggests that DCX plays a key role in the migration of new neurons in the brain of adult songbirds as it presumably does during ontogeny. (c) 2007 Elsevier B.V. All rights reserved.
http://hdl.handle.net/2268/11030
10.1016/j.jchemneu.2007.02.002

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
557_2007 Boseret et al 2007 CHENEU.pdfPublisher postprint2.53 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.