ORBi: Boyère Cédric - Combination of lipase catalysis and thiol-Michael addition for the synthesis of carbohydrate esters used as stabilizers in supercritical carbon dioxide emulsions

Reference : Combination of lipase catalysis and thiol-Michael addition for the synthesis of carbohyd...


	Document type :	Scientific congresses and symposiums : Poster
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry Engineering, computing & technology : Materials science & engineering
	To cite this reference:	http://hdl.handle.net/2268/110187

Title :	Combination of lipase catalysis and thiol-Michael addition for the synthesis of carbohydrate esters used as stabilizers in supercritical carbon dioxide emulsions
Language :	English
Author, co-author :	Boyère, Cédric [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Favrelle, Audrey [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Broze, Guy [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Paquot, Michel [University of Liège (ULg) > Gembloux Agro-Bio Tech > Unit of Biological and Industrial Chemistry > >]
	Blecker, Christophe [University of Liège (ULg) > Gembloux Agro-Bio Tech > Laboratory of Food Technology > >]
	Jérôme, Christine [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Debuigne, Antoine [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Publication date :	21-Nov-2011
Peer reviewed :	No
On invitation :	No
Audience :	National
Event name :	PAI P6/27 Annual Meeting
Event date :	21/11/2011 - 22/11/2011
Event place (city) :	Leuven
Event country :	Belgium
Keywords :	[en] enzymatic reaction
Abstract :	[en] The use of aqueous dispersed media, such as emulsions and miniemulsions, has many advantages over solution processes for chemical transformations and polymerization reactions, i.e. limited environmental impact, ease of products recovery and increased reaction rate. Although, dispersed media are usually implemented from water/solvent mixtures, supercritical carbon dioxide (scCO2) (Pc =74 bars; Tc = 31°C) constitutes an interesting alternative to the traditional organic solvents because it is inexpensive, non-toxic, non-flammable and environmentally friendlier. In this context, we develop a novel class of surface active compounds able to stabilize water/scCO2 emulsions, i.e. fluorinated modified carbohydrates. The hydrophilic head of the surfactant consists in a sugar moiety whereas the fluorinated tail has a strong affinity for the scCO2 phase. These carbohydrate esters are prepared by a two-step strategy which takes advantage of the selectivity of enzymatic catalysis and the versatility of the thiol-Michael addition reaction. The new thiolated mannose intermediate is a useful building block for the incorporation of unprotected sugar moieties into complex molecules. The surface active properties of the fluorinated derivatives have been evaluated as well as their use as stabilizers for the preparation of microparticles and highly porous polymer materials in scCO2.
Research units :	Center for Education and Research on Macromolecules (CERM)
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The ARC program SUPERZYM
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/110187
Commentary :	This poster was presented by Cédric Boyère

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