Reference : Stealth properties of poly(ethylene oxide)-based triblock copolymer micelles: A prere...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/110136
Stealth properties of poly(ethylene oxide)-based triblock copolymer micelles: A prerequisite for a pH-triggered targeting system
English
Van Butsele, Kathy [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Morille, M. [LUNAM Université et INSERM, Angers, France > > Ingénierie de la Vectorisation Particulaire > >]
Passirani, Catherine [LUNAM Université et INSERM, Angers, France > > Ingénierie de la Vectorisation Particulaire > >]
Legras, P. [University of Angers, France > > Service Commun Animalerie Hospito-Universitaire > >]
Benoit, J.-P. [LUNAM Université et INSERM, Angers, France > > Ingénierie de la Vectorisation Particulaire > >]
Varshney, S. K. [Polymer Source, Montreal, Canada > > > >]
Jérôme, Robert mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Oct-2011
Acta Biomaterialia
Elsevier Science
7
10
3700-3707
Yes (verified by ORBi)
International
1742-7061
Oxford
United Kingdom
[en] self-assembly in solution ; micelle ; stimuli responsive micelle
[en] Evaluation of the biocompatibility of pH-triggered targeting micelles was performed with the goal of studying the effect of a poly(ethylene oxide) (PEO) coating on micelle stealth properties. Upon protonation under acidic conditions, pH-sensitive poly(2-vinylpyridine) (P2VP) blocks were stretched, exhibiting positive charges at the periphery of the micelles as well as being a model targeting unit. The polymer micelles were based on two different macromolecular architectures, an ABC miktoarm star terpolymer and an ABC linear triblock copolymer, which combined three different polymer blocks, i.e. hydrophobic poly(E-caprolactone), PEO and P2VP. Neutral polymer micelles were formed at physiological pH. These systems were tested for their ability to avoid macrophage uptake, their complement activation and their pharmacological behavior after systemic injection in mice, as a function of their conformation (neutral or protonated). After protonation, complement activation and macrophage uptake were up to twofold higher than for neutral systems. By contrast, when P2VP blocks and the targeting unit were buried by the PEO shell at physiological pH, micelle stealth properties were improved, allowing their future systemic injection with an expected long circulation in blood. Smart systems responsive to pH were thus developed which therefore hold great promise for targeted drug delivery to an acidic tumoral environment.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA
Researchers
http://hdl.handle.net/2268/110136
10.1016/j.actbio.2011.06.014
http://pdn.sciencedirect.com/science?_ob=MiamiImageURL&_cid=273258&_user=532038&_pii=S1742706111002510&_check=y&_origin=browse&_zone=rslt_list_item&_coverDate=2011-10-31&wchp=dGLzVBA-zSkzS&md5=05723dfbd388a04569a21367c70f53da/1-s2.0-S1742706111002510-main.pdf

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