Reference : Voluntary brain processing in disorders of consciousness
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
http://hdl.handle.net/2268/110088
Voluntary brain processing in disorders of consciousness
English
Schnakers, Caroline mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Perrin, F. [> >]
Schabus, M. [> >]
Majerus, Steve mailto [Université de Liège - ULg > Département des sciences cognitives > Psychopathologie cognitive >]
Ledoux, Didier mailto [Université de Liège - ULg > > Soins intensifs >]
Damas, Pierre mailto [Université de Liège - ULg > > Soins intensifs >]
Boly, Mélanie mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Vanhaudenhuyse, Audrey mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Bruno, Marie-Aurélie mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Moonen, Gustave mailto [Université de Liège - ULg > > Neurologie Sart Tilman >]
Laureys, Steven mailto [Université de Liège - ULg > > Neurologie Sart Tilman >]
2008
Neurology
Lippincott Williams & Wilkins
71
20
1614-1620
Yes (verified by ORBi)
International
0028-3878
1526-632X
Hagerstown
MD
[en] Background: Disentangling the vegetative state from the minimally conscious state is often difficult when relying only on behavioral observation. In this study, we explored a new active evoked related potentials paradigm as an alternative method for the detection of voluntary brain activity.
Methods: The participants were 22 right-handed patients (10 traumatic) diagnosed as being in a
vegetative state (VS) (n 8) or in a minimally conscious state (MCS) (n 14). They were presented sequences of names containing the patient’s own name or other names, in both passive and active conditions. In the active condition, the patients were instructed to count her or his own name or to count another target name.
Results: Like controls, MCS patients presented a larger P3 to the patient’s own name, in the
passive and in the active conditions. Moreover, the P3 to target stimuli was higher in the active
than in the passive condition, suggesting voluntary compliance to task instructions like controls.
These responses were even observed in patients with low behavioral responses (e.g., visual fixationand pursuit). In contrast, no P3 differences between passive and active conditions were
observed for VS patients.
Conclusions: The present results suggest that active evoked-related potentials paradigms may
permit detection of voluntary brain function in patients with severe brain damage who present
with a disorder of consciousness, even when the patient may present with very limited to questionablyany signs of awareness.
Researchers ; Professionals
http://hdl.handle.net/2268/110088

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