Reference : Renal replacement therapy is an independent risk factor for mortality in critically i...
Scientific journals : Article
Human health sciences : Gastroenterology & hepatology
Renal replacement therapy is an independent risk factor for mortality in critically ill patients with acute kidney injury
Elseviers, M. M. [> >]
Lins, Robert L [> >]
Van der Niepen, Patricia [> >]
Hoste, Eric [> >]
Malbrain, Manu L [> >]
DAMAS, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
Devriendt, Jacques [> >]
Sharf investigators [> >]
Critical Care
BioMed Central
Yes (verified by ORBi)
United Kingdom
[en] Acute Kidney Injury/mortality/therapy ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Critical Illness/mortality ; Female ; Humans ; Male ; Middle Aged ; Renal Replacement Therapy/adverse effects/mortality ; Risk Factors ; Treatment Outcome ; Young Adult
[en] INTRODUCTION: Outcome studies in patients with acute kidney injury (AKI) have focused on differences between modalities of renal replacement therapy (RRT). The outcome of conservative treatment, however, has never been compared with RRT.
METHODS: Nine Belgian intensive care units (ICUs) included all adult patients consecutively admitted with serum creatinine >2 mg/dl. Included treatment options were conservative treatment and intermittent or continuous RRT. Disease severity was determined using the Stuivenberg Hospital Acute Renal Failure (SHARF) score.
Outcome parameters studied were mortality, hospital length of stay and renal recovery at hospital discharge. RESULTS: Out of 1,303 included patients, 650 required RRT (58% intermittent, 42% continuous RRT). Overall results showed a higher mortality (43% versus 58%) as well as a longer ICU and hospital stay in RRT patients compared to conservative treatment. Using the SHARF score for adjustment of disease severity, an increased risk of death for RRT compared to conservative treatment of RR = 1.75 (95% CI: 1.4 to 2.3) was found. Additional correction for other severity parameters (Acute Physiology And Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA)), age, type of AKI and clinical conditions confirmed the higher mortality in the RRT group.
CONCLUSIONS: The SHARF study showed that the higher mortality expected in AKI patients receiving RRT versus conservative treatment can not only be explained by a higher disease severity in the RRT group, even after multiple corrections. A more critical approach to the need for RRT in AKI patients seems to be arranted

File(s) associated to this reference

Fulltext file(s):

Restricted access
CRIT CARE 2010 14 6 R221.pdfPublisher postprint926.18 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.