Reference : Impact of aortic stiffness on left ventricular function and B-type natriuretic peptid...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
Human health sciences : General & internal medicine
http://hdl.handle.net/2268/109734
Impact of aortic stiffness on left ventricular function and B-type natriuretic peptide release in severe aortic stenosis.
English
Rosca, M. [> >]
Magne, Julien mailto [Université de Liège - ULg > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation >]
Calin, A. [> >]
Popescu, B. A. [> >]
Pierard, Luc mailto [Université de Liège - ULg > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation >]
Lancellotti, Patrizio mailto [Université de Liège - ULg > Département des sciences cliniques > Imagerie cardiaque fonctionnelle par échographie >]
2011
European Journal of Echocardiography
Harcourt Publishers Limited
12
11
850-856
Yes (verified by ORBi)
International
1525-2167
1532-2114
[en] Aortic valve disease ; Haemodynamics ; Cardiac remodelling ; Diastolic dysfunction ; Strain
[en] Aims: In aortic stenosis (AS), both reduced systemic arterial compliance and increased valvular load have been shown to contribute to impaired left ventricular (LV) function. However, the relationship between LV function and aortic stiffness has not yet been investigated. We aimed to assess the relationship between aortic stiffness and LV global longitudinal strain (GLS), LV filling pressures (E/E′) and B-type natriuretic peptide (BNP) in AS.
<br />Methods and results : A comprehensive echocardiogram was performed in 48 consecutive patients with severe AS (,0.6 cm2/m2) and preserved LV ejection fraction (≥50%). Aortic stiffness index (beta) was calculated based on aortic diameters measured by echocardiography and blood pressure. Systemic arterial compliance (SAC) and valvulo-arterial impedance (Zva)
<br />were also determined. Aortic beta index was significantly correlated with Zva (r ¼ 0.30, P ¼ 0.03) and SAC (r ¼ 20.29, P ¼ 0.04). GLS (r ¼ 0.45, P ¼ 0.001), E/E′ (r ¼ 0.48, P ¼ 0.001) and BNP levels (r ¼ 0.45, P ¼ 0.001) were significantly related to aortic beta index. No significant correlation was found between GLS or E/E′ and SAC or Zva. In multivariate regression analysis, aortic beta index remained correlated with GLS, E/E′, and BNP levels.
<br />Conclusions : In patients with severe AS and preserved LV ejection fraction, independently of the valvular load, an increase in aortic rigidity, as assessed by aortic beta index, is independently correlated with reduced LV longitudinal function, increased LV filling pressures, and BNP levels.
Service de Cardiologie
Researchers ; Professionals
http://hdl.handle.net/2268/109734
also: http://hdl.handle.net/2268/140789
10.1093/ejechocard/jer120
http://ehjcimaging.oxfordjournals.org/content/12/11/850.full.pdf+html

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