Article (Scientific journals)
Left atrial function and remodelling in aortic stenosis.
O'Connor, K.; Magne, Julien; Rosca, M. et al.
2011In European Journal of Echocardiography, 12 (4), p. 299-305
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Keywords :
Left atrial phasic volume; Left atrial function; Strain rate; Aortic stenosis; Atrial function; Doppler imagin
Abstract :
[en] AIMS: The present study sought to determine the relationship between left atrial (LA) volume (structural changes) and LA function as assessed by strain rate imaging in patients with aortic stenosis (AS). <br />METHODS AND RESULTS: The study consisted of a total of 64 consecutive patients with severe AS (<1 cm²) and 20 healthy control subjects. The phasic LA volumes and function (tissue Doppler-derived strain) were assessed in all patients. As compared with healthy controls, all strain-derived parameters of LA function were reduced in patients with AS. Conversely, only indexed LA passive volume (increased) (7.6 ± 3.8 vs. 10.5 ± 5.1 ml/m², P= 0.02) and LA active fraction (decreased) (43 ± 6.7 vs. 31 ± 13.3%, P< 0.001) (volume-based parameters) were significantly different between AS and controls. In AS, LA volume-derived function parameters were poorly correlated with LA strain parameters. In fact, by multivariable analysis, no LA phasic strain parameters emerged as independently associated with LA phasic volume parameters. <br />CONCLUSIONS: In AS, changes in LA function did not parallel changes in LA size. Furthermore, the increase in LA volume does not necessarily reflect the presence of intrinsic LA dysfunction
Research center :
Service de Cardiologie
Disciplines :
Cardiovascular & respiratory systems
General & internal medicine
Author, co-author :
O'Connor, K.
Magne, Julien ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Rosca, M.
Pierard, Luc ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Lancellotti, Patrizio  ;  Université de Liège - ULiège > Département des sciences cliniques > Imagerie cardiaque fonctionnelle par échographie
Language :
English
Title :
Left atrial function and remodelling in aortic stenosis.
Publication date :
April 2011
Journal title :
European Journal of Echocardiography
ISSN :
1525-2167
eISSN :
1532-2114
Publisher :
Harcourt Publishers Limited
Volume :
12
Issue :
4
Pages :
299-305
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 January 2012

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