Article (Scientific journals)
Invasion and metastatic dissemination in breast cancer: mechanisms
Noël, Agnès; Gilles, Christine; Foidart, Jean-Michel
2011In Revue Médicale de Liège, 66 (5-6), p. 274-278
Peer reviewed
 

Files


Full Text
Noel A Invasion RMLG 2011.pdf
Publisher postprint (371.84 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Metastases; Metastatic niche; Cancer stem cells; epithelial to mesenchymal transition; molecular signature
Abstract :
[en] Metastases formation is a complex process involving genetic and epigenetic modifications leading to several molecular pathway dysfunctions and alterations in the production and fonction of a panel of molecular mediators. Recent studies have shed light on the importance of multiple interactions occuring between tumor cells and host cells involved in the elaboration of a microenvironment permissive for tumor cell survival and growth. These tumor-host interactions are decisive, not only in the primary tumor, but also in secondary sites colonized by tumor cells. Cancer appears more and more as a sytemic disease in which tumor cell is one of the pawn in the game. System of defense are rapidly overwhelmed and tumor cells hijack host cells to promote their dissemination that likely occurs at earlier stages than initially anticipated. In the present review, we describe the novel concepts of metastases formation based on recent transcriptomic analyses and new insights acquired on the tumor microenvironment in the primary tumor and in secondary foci.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Noël, Agnès ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme
Gilles, Christine ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Language :
English
Title :
Invasion and metastatic dissemination in breast cancer: mechanisms
Publication date :
2011
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Hopital de Baviere, Liège, Belgium
Volume :
66
Issue :
5-6
Pages :
274-278
Peer reviewed :
Peer reviewed
European Projects :
FP7 - 201279 - MICROENVIMET - Understanding and fighting metastasis by modulating the tumour microenvironment through interference with the protease network.
Funders :
CE - Commission Européenne [BE]
Available on ORBi :
since 24 January 2012

Statistics


Number of views
212 (8 by ULiège)
Number of downloads
972 (9 by ULiège)

Scopus citations®
 
6
Scopus citations®
without self-citations
5

Bibliography


Similar publications



Contact ORBi