Reference : Adult final height after GH therapy for irradiation-induced GH deficiency in childhoo...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/109521
Adult final height after GH therapy for irradiation-induced GH deficiency in childhood survivors of brain tumors: the Belgian experience.
English
Beckers, D. [> > > >]
THOMAS, M. [ > > ]
Jamart, J. [> > > >]
FRANCOIS, I. [ > > ]
MAES, M. [ > > ]
LEBRETHON, Marie-Christine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pédiatrie]
De Waele, K. [> > > >]
Tenoutasse, S. [> > > >]
De Schepper, J. [> > > >]
2010
European Journal of Endocrinology
BioScientifica Ltd
162
3
483-90
Yes (verified by ORBi)
International
0804-4643
1479-683X
Bristol
United Kingdom
[en] Adolescent ; Adult ; Age Factors ; Belgium ; Body Height/drug effects/radiation effects ; Brain Neoplasms/radiotherapy ; Chi-Square Distribution ; Child ; Child, Preschool ; Databases, Factual ; Female ; Human Growth Hormone/deficiency/therapeutic use ; Humans ; Hypopituitarism/etiology ; Infant ; Male ; Patient Selection ; Pituitary Gland/physiopathology/radiation effects ; Radiotherapy/adverse effects ; Regression Analysis ; Retrospective Studies ; Sex Factors ; Statistics, Nonparametric ; Survivors
[en] OBJECTIVES: The treatment of brain tumors in childhood is frequently complicated by growth retardation with a high proportion of irradiation (Irr)-induced GH deficiency (GHD) resulting in reduced adult final height (AFH) even after GH therapy (GHT). In order to optimize future GHT protocols, more information on the factors influencing the growth response to GH in these children is needed. This retrospective study evaluated AFH and influencing auxological and treatment factors of a standardized daily biosynthetic GHT in childhood survivors of brain tumors with documented GHD after brain Irr. DESIGN AND METHODS: From the Belgian GH Registry, 57 children survivors of a brain tumor outside the hypothalamo-pituitary area with available AFH were stratified into two groups depending on cranial (C-Irr; n=25) or craniospinal (CS-Irr; n=32) Irr. RESULTS: In the C-Irr patients, results showed an AFH of -0.8 (-2.5, 1.4) SDS (median (range)) and in the CS-Irr patients, results showed a significantly (P<0.001) lower AFH of -1.8 (-4.2, 0.0) SDS. AFH SDS corrected for mid-parental height (MPH) in the C-Irr group was -0.5 (-2.2, 0.9) and -1.5 (-3.6, 0.0) SDS in the CS-Irr group. AFH was positively correlated with age at end of tumor therapy, height SDS at start GHT, height gain SDS first year GHT, and negatively correlated with CS-Irr. CONCLUSIONS: GHT failed to restore adult height to MPH in nearly half of Irr-induced GHD patients for brain tumor, especially those receiving CS-Irr, irradiated at a younger age or shorter at start GHT.
http://hdl.handle.net/2268/109521
10.1530/EJE-09-0690

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Beckers D et al (adult final height after GH...) Eur J Endocrinol 2010.pdfPublisher postprint169.88 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.