Reference : Biological aspects of angiogenesis in multiple myeloma.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/109519
Biological aspects of angiogenesis in multiple myeloma.
English
Otjacques, Eléonore mailto [Université de Liège - ULg > > GIGA-R : Hématologie >]
Binsfeld, Marilène mailto [Université de Liège - ULg > > GIGA-R : Hématologie >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Beguin, Yves mailto [Université de Liège - ULg > > GIGA-R : Hématologie >]
Cataldo, Didier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path. >]
CAERS, Jo mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
2011
International Journal of Hematology
Carden Jennings Publishing
94
6
505-18
Yes (verified by ORBi)
International
0925-5710
Charlottesville
VA
[en] Multiple myeloma ; Angiogenesis ; Hypoxia ; Endothelial cell ; Bone marrow microenvironment
[en] Multiple myeloma (MM) is a hematological malignancy characterized by the aberrant expansion of malignant plasma cells within the bone marrow (BM). One of the hallmarks of this disease is the close interaction between myeloma cells and neighboring cells within the BM. Angiogenesis, through the activation of endothelial cells, plays an essential role in MM biology. In the current review, we describe the angiogenesis process in MM by identifying the interacting cells, the pro- and anti-angiogenic cytokines modulated, and the extracellular matrix degrading proteases liable to participate in the pathophysiology. Finally, we highlight the impact of hypoxia (through hypoxia-inducible factor-1) and constitutive activation of nuclear factor-κB in this tumor-induced neo-vascularization.
http://hdl.handle.net/2268/109519
10.1007/s12185-011-0963-z

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