ORBi: Nguyen Ngoc-Quynh-Nhu - The antiangiogenic 16K prolactin disturbs functional tumor neovascularization by affecting vessel maturation

Reference : The antiangiogenic 16K prolactin disturbs functional tumor neovascularization by affecti...


	Document type :	Scientific congresses and symposiums : Poster
	Discipline(s) :	Human health sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/2268/109047

Title :	The antiangiogenic 16K prolactin disturbs functional tumor neovascularization by affecting vessel maturation
Language :	English
Author, co-author :	Nguyen, Ngoc-Quynh-Nhu [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire > > >]
	Castermans, Karolien [Université de Liège - ULg > Département des sciences de la vie > Giga-R: Biologie et Génétique moléculaire > >]
	Berndt, Sarah [Université de Liège - ULg > Département des sciences cliniques > Giga-R: Labo de biologie des tumeurs et du développement > >]
	Herkenne, Stéphanie [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
	Tabruyn, Sébastien [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
	Blacher, Silvia [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement > > >]
	Lion, Michelle [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
	Noël, Agnès [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
	Martial, Joseph [Université de Liège - ULg > Département des sciences de la vie > Département des sciences de la vie >]
	Struman, Ingrid [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Publication date :	May-2011
Audience :	International
Event name :	4th International Meeting on Angiogenesis
Event place (city) :	Amsterdam
Event country :	The Netherlands
Keywords :	[en] 16K hPRL ; angiogenesis ; vessel maturation
Abstract :	[en] 16K hPRL, the antiangiogenic 16-kDa N-terminal fragment of human prolactin was shown to prevent tumor growth and metastasis by modifying tumor vessel morphology. Here we investigated the effect of 16K hPRL on tumor vessel maturation and on the related signaling pathways. We show that 16K hPRL treatment leads, in a murine B16-F10 tumor model, to a dysfunctional tumor vasculature with reduced pericyte coverage, and disruption of the PDGF-B/PDGFR-B, Ang/Tie2, and Delta/Notch pathways. In an aortic ring assay, 16K hPRL impairs endothelial cell and pericyte outgrowth from the vascular ring. In addition, 16K hPRL prevents pericyte migration to endothelial cells. This event was independent of a direct inhibitory effect of 16K hPRL on pericyte viability, proliferation, or migration. In endothelial cell-pericyte cocultures, we found 16K hPRL to disturb Notch signaling, this being the first time such an effect is observed with an endogenous antiangiogenic agent. These findings provide new insights into the mechanisms of 16K hPRL action and highlight its potential for use in anticancer therapy.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/109047

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