[en] Sleep is believed to participate in memory consolidation, possibly through off-line processing of recent memory traces. In this paper, we summarize functional neuroimaging data testing this hypothesis. First, sleep deprivation disrupts the processing of recent memory traces and hampers the changes in functional segregation and connectivity which underpin the gain in performance usually observed in subjects allowed to sleep on the first post-training night. Second, experience-dependent changes in regional brain activity occur during post-training sleep. These changes are shown to be related to the processing of high-level material and to be modulated by the amount of learning achieved during the training session. These changes do not involve isolated brain areas but entire macroscopic cerebral networks. These data suggest a role for sleep in the processing of recent memory traces.
Disciplines :
Neurology Neurosciences & behavior
Author, co-author :
Maquet, Pierre ; Université de Liège - ULiège > Centre de recherches du cyclotron
Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron
Boly, Mélanie ; Université de Liège - ULiège > Centre de Recherches du Cyclotron > Neurologie
Dang Vu, Thien Thanh ; Université de Liège - ULiège > Centre de Recherches du Cyclotron - Département des sciences cliniques > Neurologie
Desseilles, Martin ; Université de Liège - ULiège > Centre de Recherches du Cyclotron - Département des sciences cliniques > Psychiatrie et psychologie médicale
Cleeremans, Axel
Language :
English
Title :
Memory processing during human sleep as assessed by functional neuroimaging
CLEEREMANS A, McCLELLAND JL. (1991). Learning the structure of event sequences. J Exp Psychol, 120: 235-253.
DRUMMOND SP, BROWN GG, GILLIN JC, STRICKER JL, WONG EC, BUXTON RB. (2000). Altered brain response to verbal learning following sleep deprivation. Nature, 403: 655-657.
FRITH C. (1973). Learning rhythmic hand movements. Quarterly Journal of Experimental Psychology, 25: 253-259.
KRAUZLIS RJ, STONE LS. (1999). Tracking with the mind's eye. Trends Neurosci, 22: 544-550.
LAUREYS S, PEIGNEUX P, PHILLIPS C, et al. (2001). Experience-dependent changes in cerebral functional connectivity during human rapid eye movement sleep. Neuroscience, 105: 521-525.
MAQUET P. (2001). The role of sleep in learning and memory. Science, 294: 1048-52.
MAQUET P, LAUREYS S, PEIGNEUX P, et al. (2000). Experience-dependent changes in cerebral activation during human REM sleep. Nat Neurosci, 3: 831-836.
MAQUET P, SCHWARTZ S, PASSINGHAM R, FRITH C. (2003). Sleep-related consolidation of a visuo-motor skill: brain mechanisms as assessed by functional magnetic resonance imaging. J Neurosci, 23: 1432-1440.
STICKGOLD R, JAMES L, HOBSON JA. (2000). Visual discrimination learning requires sleep after training. Nat Neurosci, 3: 1237-1238.