ORBi: Linden Annick - Cardiovascular response to exogenous serotonin in healthy calves

Reference : Cardiovascular response to exogenous serotonin in healthy calves


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Veterinary medicine & animal health
	To cite this reference:	http://hdl.handle.net/2268/108961

Title :	Cardiovascular response to exogenous serotonin in healthy calves
Language :	English
Author, co-author :	Linden, Annick [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Santé et pathologies de la faune sauvage >]
	Desmecht, Daniel [Université de Liège - ULg > Département de morphologie et pathologie > Pathologie spéciale et autopsies >]
	Amory, Hélène [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Médecine interne des équidés >]
	Beduin, Jean-Marie [Université de Liège - ULg > Services généraux (Faculté de médecine vétérinaire) > Scientifiques attachés au Doyen (F MV) >]
	Lekeux, Pierre [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie >]
Publication date :	May-1996
Journal title :	American Journal of Veterinary Research
Publisher :	American Veterinary Medical Association
Volume :	57
Issue/season :	5
Pages :	731-738
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0002-9645
City :	Schaumburg
Country :	IL
Keywords :	[en] serotonin ; 5-hydroxytryptamine ; lung
Abstract :	[en] OBJECTIVE: To characterize the cardiovascular response to i.v. administration of serotonin (5-hydroxytryptamine [5-HT]) in calves. ANIMALS: 5 healthy unsedated Friesian calves. PROCEDURE: 41 5-HT administrations were performed: II slow infusions (duration, 5 minutes) and 30 bolus infusions (duration, 5 seconds). Cardiovascular function values were recorded before, during, and after the infusion. RESULTS: Slow infusion of 5HT first resulted in a brief period of severe bradycardia, then in sustained tachycardia with a concomitant increase in cardiac output. Systemic initial hypotension concomitant with bradycardia, then a pressor phase associated with an increase in systemic vascular resistance, and finally, a long-lasting hypotensive phase associated with decreased systemic vascular resistance. Pulmonary hypertension was associated with increased pulmonary vascular resistance, reflecting intense pulmonary vasoconstriction. Bolus infusion at increasing dosages resulted in dose-dependent bradycardia and systemic hypotension, followed by dose-dependent systemic hypertension. Unlike with slow infusion, neither the second tachycardiac nor the third systemic hypotensive phases were evident. CONCLUSIONS: 5-HT induces dose-dependent cardiovascular responses, including a reflex response followed by pulmonary and systemic vasoconstriction, in healthy calves. CLINICAL RELEVANCE: Determining the type of serotonergic receptors responsible for these responses may help to determine whether 5-HT is involved in the mechanisms underlying brisket disease in cattle.
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/108961

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