ORBi: Geenen Vincent - The presentation of neuroendocrine self in the thymus: a necessity for an integrated evolution of the immune and neuroendocrine systems.

Reference : The presentation of neuroendocrine self in the thymus: a necessity for an integrated evo...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Immunology & infectious disease Human health sciences : Endocrinology, metabolism & nutrition
	To cite this reference:	http://hdl.handle.net/2268/108809

Title :	The presentation of neuroendocrine self in the thymus: a necessity for an integrated evolution of the immune and neuroendocrine systems.
Language :	English
Author, co-author :	Geenen, Vincent [Université de Liège - ULg > > Centre d'immunologie >]
Publication date :	2012
Journal title :	Annals of the New York Academy of Sciences
Publisher :	New York Academy of Sciences
Volume :	1261
Special issue title :	Proceedings of the ISNIM Congress in Dresden (2011)
Pages :	42-48
Audience :	International
ISSN :	0077-8923
City :	New York
Country :	NY
Keywords :	[en] Thymus ; Antigen presentation ; Central self-tolerance ; Autoimmunity ; AIRE ; Type 1 diabetes ; IGF-2 ; Graves' disease
Abstract :	[en] During evolution, from ancestor thymoids scattered in gill baskets of the lamprey, the first unique thymus appeared in jawed cartilaginous fishes around 450-500 millions years ago, concomitantly or shortly after the emergence of recombinase-dependent adaptive immunity. The major biological function of the thymus is to generate a diverse repertoire of T-cell receptors that are self-tolerant. The thymus achieves this role by using two complementary and intimately associated mechanisms: 1) Apoptotic deletion of T-cell clones bearing a TCR with high affinity for self-antigens presented by MHC proteins on thymic epithelial cells (TECs) and dendritic cells (DCs); and 2) Generation of self-antigen specific natural regulatory T (nTreg) cells. Moreover, the escape from thymic central self-tolerance plays a primary role in the development of autoimmune diseases that are a significant burden for the quality of life and health care cost. Our new knowledge in thymus physiology and physiopathology is currently translated into innovative therapeutic strategies against these devastating chronic diseases.
Research units :	Centre d'Immunologie ULg (CIL)
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Léon Fredericq ; Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE ; European Association for the Study of Diabetes (EASD) ; Juvenile Diabetes Research Federation (JDRF) ; Union Européenne = European Union - UE = EU
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/108809
Other URL :	http://www.psychologie.tu-dresden.de/isnim2011/

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