Article (Scientific journals)
The presentation of neuroendocrine self in the thymus: a necessity for an integrated evolution of the immune and neuroendocrine systems.
Geenen, Vincent
2012In Annals of the New York Academy of Sciences, 1261, p. 42-48
Peer Reviewed verified by ORBi
 

Files


Full Text
ANYAS_2012.pdf
Publisher postprint (601.68 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Thymus; Antigen presentation; Central self-tolerance; Autoimmunity; AIRE; Type 1 diabetes; IGF-2; Graves' disease
Abstract :
[en] During evolution, from ancestor thymoids scattered in gill baskets of the lamprey, the first unique thymus appeared in jawed cartilaginous fishes around 450-500 millions years ago, concomitantly or shortly after the emergence of recombinase-dependent adaptive immunity. The major biological function of the thymus is to generate a diverse repertoire of T-cell receptors that are self-tolerant. The thymus achieves this role by using two complementary and intimately associated mechanisms: 1) Apoptotic deletion of T-cell clones bearing a TCR with high affinity for self-antigens presented by MHC proteins on thymic epithelial cells (TECs) and dendritic cells (DCs); and 2) Generation of self-antigen specific natural regulatory T (nTreg) cells. Moreover, the escape from thymic central self-tolerance plays a primary role in the development of autoimmune diseases that are a significant burden for the quality of life and health care cost. Our new knowledge in thymus physiology and physiopathology is currently translated into innovative therapeutic strategies against these devastating chronic diseases.
Research center :
Centre d'Immunologie ULiège (CIL)
Disciplines :
Endocrinology, metabolism & nutrition
Immunology & infectious disease
Author, co-author :
Geenen, Vincent ;  Université de Liège - ULiège > Centre d'immunologie
Language :
English
Title :
The presentation of neuroendocrine self in the thymus: a necessity for an integrated evolution of the immune and neuroendocrine systems.
Publication date :
2012
Journal title :
Annals of the New York Academy of Sciences
ISSN :
0077-8923
eISSN :
1749-6632
Publisher :
New York Academy of Sciences, New York, United States - New York
Special issue title :
Proceedings of the ISNIM Congress in Dresden (2011)
Volume :
1261
Pages :
42-48
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Fonds Léon Fredericq [BE]
DGTRE - Région wallonne. Direction générale des Technologies, de la Recherche et de l'Énergie [BE]
EASD - European Association for the Study of Diabetes [DE]
JDRF - Juvenile Diabetes Research Foundation [CA]
UE - Union Européenne [BE]
Available on ORBi :
since 19 January 2012

Statistics


Number of views
118 (4 by ULiège)
Number of downloads
284 (3 by ULiège)

Scopus citations®
 
9
Scopus citations®
without self-citations
7
OpenCitations
 
9

Bibliography


Similar publications



Contact ORBi