Reference : A genome-wide linkage study of individuals with high scores on NEO personality traits
Scientific journals : Article
Human health sciences : Psychiatry
http://hdl.handle.net/2268/108429
A genome-wide linkage study of individuals with high scores on NEO personality traits
English
Amin, Najaf mailto [Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology > > >]
Schuur, M. [Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology > > >]
Gusareva, Elena mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique >]
Isaacs, Aaron mailto [Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology > > >]
Aulchenko, Yuri mailto [Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology > > >]
Kirichenko, A. V. [Institute of Cytology and Genetics, Russian Academy of Science, Novosibirsk, Russia > > > >]
Zorkoltseva, I. V. [Institute of Cytology and Genetics, Russian Academy of Science, Novosibirsk, Russia > > > >]
Axenovich, Tatyana [Novosibirsk State University, Novosibirsk, Russia > Department of Cytology and Genetics > > >]
Oostra, B. A. [Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology > > >]
Janssens, ACJW [Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology > > >]
van Duijn, Cornelia M mailto [Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology > > >]
9-Aug-2011
Molecular Psychiatry
Nature Publishing Group
Yes (verified by ORBi)
International
1359-4184
1476-5578
Houndmills
United Kingdom
[en] CNV ; family ; haplotype ; linkage ; NEO ; pedigree
[en] The NEO-Five-Factor Inventory divides human personality traits into five dimensions: neuroticism,
extraversion, openness, conscientiousness and agreeableness. In this study, we sought to identify
regions harboring genes with large effects on the five NEO personality traits by performing
genome-wide linkage analysis of individuals scoring in the extremes of these traits ( > 90th
percentile). Affected-only linkage analysis was performed using an Illumina 6K linkage array
in a family-based study, the Erasmus Rucphen Family study. We subsequently determined
whether distinct, segregating haplotypes found with linkage analysis were associated with the
trait of interest in the population. Finally, a dense single-nucleotide polymorphism genotyping
array (Illumina 318K) was used to search for copy number variations (CNVs) in the associated
regions. In the families with extreme phenotype scores, we found significant evidence of
linkage for conscientiousness to 20p13 (rs1434789, log of odds (LOD) = 5.86) and suggestive
evidence of linkage (LOD > 2.8) for neuroticism to 19q, 21q and 22q, extraversion to 1p, 1q, 9p
and12q, openness to 12q and 19q, and agreeableness to 2p, 6q, 17q and 21q. Further analysis
determined haplotypes in 21q22 for neuroticism (P-values = 0.009, 0.007), in 17q24 for
agreeableness (marginal P-value = 0.018) and in 20p13 for conscientiousness (marginal
P-values = 0.058, 0.038) segregating in families with large contributions to the LOD scores.
No evidence for CNVs in any of the associated regions was found. Our findings imply that
there may be genes with relatively large effects involved in personality traits, which may be
identified with next-generation sequencing techniques.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/108429
10.1038/mp.2011.97
http://www.ncbi.nlm.nih.gov/pubmed/21826060

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