Reference : Stimulant effects of ethanol in adolescent Swiss mice: development of sensitization and ...
Scientific congresses and symposiums : Paper published in a journal
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/108420
Stimulant effects of ethanol in adolescent Swiss mice: development of sensitization and consequences in adulthood
English
Quoilin, Caroline [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Psychologie quantitative >]
Didone, Vincent mailto [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Psychologie quantitative >]
Quertemont, Etienne mailto [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Psychologie quantitative >]
2011
Alcohol & Alcoholism
Oxford University Press
46
Supplément 1
i40
Yes (verified by ORBi)
No
International
0735-0414
1464-3502
Oxford
United Kingdom
13th Congress of the European Society for Biomedical Research on alcoholism
4-7 Septembre 2011
European Society for Biomedical Research on alcoholism
Vienne
Autriche
[en] Ethanol ; Mice ; Sensitization ; Adolescence
[en] The adolescent period is characterized by behavioral and neurobiological changes, which might predispose adolescents to the long-term negative consequences of alcohol. For example, enhanced risks of alcohol dependence are reported when drinking is initiated early. In the present studies, we used Swiss female mice to test whether chronic ethanol injections during adolescence durably affect the sensitivity to the stimulant effects of ethanol in adulthood. In a first set of experiments, several groups of young (28 day-old) mice were daily injected with various ethanol doses (1.5 – 4 g/kg) to test for ethanol sensitization during adolescence in comparison to adult mice exposed to the same schedule of ethanol injections. The results show that young mice express much higher stimulant effects after acute ethanol injections. However, they also require higher ethanol doses than adult mice to develop a sensitization to the stimulant effects of ethanol. In a second set of experiments, 28 day-old mice were sensitized to ethanol for 14 days with high ethanol doses (2.5 or 4 g/kg) and then tested for the stimulant effects of ethanol and the development of ethanol sensitization in adulthood. The results of this second set of experiments show that mice sensitized to ethanol during their adolescence remain more sensitive to the acute stimulant effects of ethanol in adulthood, especially when high ethanol doses were administered. However, the rate of the development of a sensitization to this effect was only slightly affected relative to adult mice exposed to a chronic ethanol regimen for the first time. Together, these results indicate that adolescent mice are more sensitive to the stimulant effects of ethanol but require higher ethanol doses to develop a sensitization. However, when a sensitization develops during adolescence, these mice still experience higher ethanol stimulant effects when tested in adulthood.
Centre de Neurosciences Cognitives et Comportementales
Researchers ; Professionals
http://hdl.handle.net/2268/108420
Prix du meilleur poster de l'European society for Biomedical Research on Alcoholism

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