ORBi: Quoilin Caroline - Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice

Reference : Developmental differences in ethanol-induced sensitization using postweanling, adolescen...


	Document type :	Scientific journals : Article
	Discipline(s) :	Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/108403

Title :	Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice
Language :	English
Author, co-author :	Quoilin, Caroline [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Psychologie quantitative >]
	Didone, Vincent [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Psychologie quantitative >]
	Tirelli, Ezio [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Neuroscience comportementale et psychopharmacologie expér. >]
	Quertemont, Etienne [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Psychologie quantitative >]
Publication date :	2012
Journal title :	Psychopharmacology
Publisher :	Springer Verlag
Volume :	219
Pages :	1165-1177
Audience :	International
ISSN :	0033-3158
City :	Berlin
Country :	Germany
Keywords :	[en] Ethanol ; Adolescence ; Locomotor activity ; Behavioral sensitization ; Mice
Abstract :	[en] Rationale: The maturing adolescent brain has been suggested to be more sensitive than the adult brain to ethanol-induced neuroadaptations. In animal studies, sensitization to the stimulant effects of ethanol is used to study the vulnerability to chronic ethanol-induced neurobehavioral alterations. Objectives: The aim of the present study was to systematically characterize age-dependent changes in the development and expression of the sensitization to the stimulant effects of a range of ethanol doses in female Swiss mice. Three ages were studied: 21-day-old mice (postweanlings), 35-day-old mice (adolescents), and 63-day-old mice (adults). Methods: Postweanling, adolescent, and adult mice were daily injected with saline or various ethanol doses (1.5 to 4 g/kg) for 7 days. They were then tested for acute and sensitized locomotor activity. Results: Postweanling and adolescent mice were more sensitive than adult mice to the acute stimulant effects of ethanol. In adult mice, daily injections of ethanol at doses between 2.5 and 4 g/kg led to significant sensitization. Higher ethanol doses (3.5 and 4 g/kg) were required to induce sensitization in postweanling and adolescent mice. However, younger mice showed ethanol sensitization of higher magnitude. Conclusions: Young mice develop very strong ethanol sensitization at doses that mimic binge drinking in humans. These results might explain why early ethanol drinking during adolescence is related to a higher prevalence of subsequent alcohol disorders.
Research units :	Centre de Neurosciences Cognitives et Comportementales
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/108403
DOI :	10.1007/s00213-011-2453-7
Other URL :	http://www.springerlink.com/content/0680k44773841250/

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