|Reference : Developmental differences in ethanol-induced sensitization using postweanling, adolescen...|
|Scientific journals : Article|
|Social & behavioral sciences, psychology : Neurosciences & behavior|
|Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice|
|Quoilin, Caroline [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Psychologie quantitative >]|
|Didone, Vincent [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Psychologie quantitative >]|
|Tirelli, Ezio [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Neuroscience comportementale et psychopharmacologie expér. >]|
|Quertemont, Etienne [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Psychologie quantitative >]|
|[en] Ethanol ; Adolescence ; Locomotor activity ; Behavioral sensitization ; Mice|
|[en] Rationale: The maturing adolescent brain has been suggested to be more sensitive than the adult brain to ethanol-induced neuroadaptations. In animal studies, sensitization to the stimulant effects of ethanol is used to study the vulnerability to chronic ethanol-induced neurobehavioral alterations.
Objectives: The aim of the present study was to systematically characterize age-dependent changes in the development and expression of the sensitization to the stimulant effects of a range of ethanol doses in female Swiss mice. Three ages were studied: 21-day-old mice (postweanlings), 35-day-old mice (adolescents), and 63-day-old mice (adults).
Methods: Postweanling, adolescent, and adult mice were daily injected with saline or various ethanol doses (1.5 to 4 g/kg) for 7 days. They were then tested for acute and sensitized locomotor activity.
Results: Postweanling and adolescent mice were more sensitive than adult mice to the acute stimulant effects of ethanol. In adult mice, daily injections of ethanol at doses between 2.5 and 4 g/kg led to significant sensitization. Higher ethanol doses (3.5 and 4 g/kg) were required to
induce sensitization in postweanling and adolescent mice. However, younger mice showed ethanol sensitization of higher magnitude.
Conclusions: Young mice develop very strong ethanol sensitization at doses that mimic binge drinking in humans. These results might explain why early ethanol drinking during adolescence is related to a higher prevalence of subsequent alcohol disorders.
|Centre de Neurosciences Cognitives et Comportementales|
|Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS|
|Researchers ; Professionals|
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