ORBi: Philippe Geneviève - In vitro screening of some Strychnos species for antiplasmodial activity

Reference : In vitro screening of some Strychnos species for antiplasmodial activity


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology Physical, chemical, mathematical & earth Sciences : Chemistry Life sciences : Phytobiology (plant sciences, forestry, mycology...)
	To cite this reference:	http://hdl.handle.net/2268/10833

Title :	In vitro screening of some Strychnos species for antiplasmodial activity
Language :	English
Author, co-author :	Philippe, Geneviève [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
	Angenot, Luc [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
	De Mol, Patrick [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale]
	Goffin, Eric [Université de Liège - ULg > > Chimie pharmaceutique >]
	Hayette, Marie-Pierre [Université de Liège - ULg > > Microbiologie médicale >]
	Tits, Monique [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
	Frederich, Michel [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Publication date :	21-Mar-2005
Journal title :	Journal of Ethnopharmacology
Publisher :	Elsevier Sci Ireland Ltd
Volume :	97
Issue/season :	3
Pages :	535-539
Audience :	International
ISSN :	0378-8741
City :	Clare
Keywords :	[en] Strychnos ; Loganiaccae ; antiplasmodial ; malaria ; Plasmodium falciparum ; in vitro screening
Abstract :	[en] The antiplasmodial activity of crude extracts of 19 species of Strychnos (Loganiaceae) was assessed in vitro against a chloroquine-susceptible strain of Plasmodium falciparum. For each species, ethyl acetate (EtOAc) extracts were analysed and, for the most active species, methanolic (MeOH) extracts were also tested. Among them, Strychnos variabilis De Wild. seemed to be very promising (inhibitory concentration 50% (IC50) < 5 microg/ml) whereas two other species, Strychnos gossweileri Exell and Strychnos mellodora S. Moore, could be interesting (IC50 < 15 microg/ml) in further antimalarial studies.
Permalink :	http://hdl.handle.net/2268/10833
DOI :	10.1016/j.jep.2004.12.011

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