Reference : Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum v...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Physical, chemical, mathematical & earth Sciences : Chemistry
Life sciences : Phytobiology (plant sciences, forestry, mycology...)
http://hdl.handle.net/2268/10831
Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum
English
Otshudi, A. L. [> > > >]
Apers, S. [> > > >]
Pieters, L. [> > > >]
Claeys, Mathieu [Centre Hospitalier Universitaire de Liège - CHU > > Médecine de l'appareil locomoteur >]
Pannecouque, C. [> > > >]
De Clercq, E. [> > > >]
Van Zeebroeck, A. [> > > >]
Lauwers, S. [> > > >]
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Foriers, A. [> > > >]
31-Oct-2005
Journal of Ethnopharmacology
Elsevier Ireland Ltd
102
1
89-94
Yes (verified by ORBi)
International
0378-8741
Clare
[en] Epinetrum villosum ; Menispermaceae ; bisbenzylisoquinoline alkaloids ; antibacterial activity ; antifungal activity ; antiplasmodial activity ; anti-HIV activity
[en] Methanol and water extracts of the root of Epinetrum villosum (Exell) Troupin (Menispermaceae) were found to exhibit antimicrobial and antiplasmodial activities. Investigation of the active methanol fraction led to the isolation of four bisbenzylisoquinoline alkaloids, i.e., cycleanine, cycleanine N-oxide, isochondodendrine and cocsoline. Structures were established by spectroscopic methods. Cocsoline displayed antibacterial and antifungal activities (MIC values of 1000-15.62 and 31.25 mu g/ml, respectively). Isochondodendrine was found to have the most potent antiplasmodial activity (IC50 = 0- 10 mu g/ml), whereas the IC50 on HCT-116 human colon carcinoma cells was 17.5 mu g/ml (selectivity index 175). Cycleanine acted against HIV-2 (EC50 = 1.83 mu g/ml) but was at least 10-fold less active against HIV-1. Cycleanine N-oxide showed no activity towards all tested microorganisms. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
http://hdl.handle.net/2268/10831

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