ORBi: Otshudi A. L. - Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum

Reference : Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum vill...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology Physical, chemical, mathematical & earth Sciences : Chemistry Life sciences : Phytobiology (plant sciences, forestry, mycology...)
	To cite this reference:	http://hdl.handle.net/2268/10831

Title :	Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum
Language :	English
Author, co-author :	Otshudi, A. L. [> > > >]
	Apers, S. [> > > >]
	Pieters, L. [> > > >]
	Claeys, Mathieu [Centre Hospitalier Universitaire de Liège - CHU > > Médecine de l'appareil locomoteur >]
	Pannecouque, C. [> > > >]
	De Clercq, E. [> > > >]
	Van Zeebroeck, A. [> > > >]
	Lauwers, S. [> > > >]
	Frederich, Michel [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
	Foriers, A. [> > > >]
Publication date :	31-Oct-2005
Journal title :	Journal of Ethnopharmacology
Publisher :	Elsevier Ireland Ltd
Volume :	102
Issue/season :	1
Pages :	89-94
Audience :	International
ISSN :	0378-8741
City :	Clare
Keywords :	[en] Epinetrum villosum ; Menispermaceae ; bisbenzylisoquinoline alkaloids ; antibacterial activity ; antifungal activity ; antiplasmodial activity ; anti-HIV activity
Abstract :	[en] Methanol and water extracts of the root of Epinetrum villosum (Exell) Troupin (Menispermaceae) were found to exhibit antimicrobial and antiplasmodial activities. Investigation of the active methanol fraction led to the isolation of four bisbenzylisoquinoline alkaloids, i.e., cycleanine, cycleanine N-oxide, isochondodendrine and cocsoline. Structures were established by spectroscopic methods. Cocsoline displayed antibacterial and antifungal activities (MIC values of 1000-15.62 and 31.25 mu g/ml, respectively). Isochondodendrine was found to have the most potent antiplasmodial activity (IC50 = 0- 10 mu g/ml), whereas the IC50 on HCT-116 human colon carcinoma cells was 17.5 mu g/ml (selectivity index 175). Cycleanine acted against HIV-2 (EC50 = 1.83 mu g/ml) but was at least 10-fold less active against HIV-1. Cycleanine N-oxide showed no activity towards all tested microorganisms. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
Permalink :	http://hdl.handle.net/2268/10831

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