Reference : Screening of medicinal plants from Reunion Island for antimalarial and cytotoxic activity.
Scientific journals : Article
Life sciences : Phytobiology (plant sciences, forestry, mycology...)
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/10828
Screening of medicinal plants from Reunion Island for antimalarial and cytotoxic activity.
English
Jonville, Marie mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Kodja, H. [> > > >]
Humeau, L. [> > > >]
Fournel, J. [> > > >]
De Mol, Patrick mailto [Centre Hospitalier Universitaire de Liège - CHU > > Microbiologie médicale >]
Cao, Martine mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
2008
Journal of Ethnopharmacology
Elsevier Sequoia
120
3
382-6
Yes (verified by ORBi)
International
0378-8741
Limerick
Ireland
[en] AIM OF THE STUDY: Nine plants from Reunion Island, selected using ethnopharmacology and chemotaxonomy, were investigated for their potential antimalarial value. MATERIALS AND METHODS: Thirty-eight extracts were prepared by maceration using CH(2)Cl(2) and MeOH, and were tested for in vitro activity against the 3D7 and W2 strain of Plasmodium falciparum. The most active extracts were then tested for in vitro cytotoxicity on human WI-38 fibroblasts to determine the selectivity index. Those extracts were also investigated in vivo against Plasmodium berghei infected mice. RESULTS: Most active of the extracts tested were the dichloromethane leaves extracts of Nuxia verticillata Lam. (Buddlejaceae), Psiadia arguta Voigt. (Asteraceae), Lantana camara L. (Verbenaceae), the methanol extracts from Aphloia theiformis (Vahl) Benn. (Aphloiaceae) bark, and Terminalia bentzoe L. (Combretaceae) leaves displaying in vitro IC(50) values ranging from 5.7 to 14.1mug/ml. Extracts from Psiadia, Aphloia at 200mg/(kgday) and Teminalia at 50mg/(kgday) also exhibited significant (p<0.0005) parasite inhibition in mice: 75.5%, 65.6% and 83.5%, respectively. CONCLUSION: Two plants showed interesting antimalarial activity with good selectivity: Aphloia theiformis and Terminalia bentzoe. Nuxia verticillata still needs to be tested in vivo, with a new batch of plant material.
http://hdl.handle.net/2268/10828
10.1016/j.jep.2008.09.005

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