[fr] Différents types de canaux potassiques sont impliqués dans le contrôle de l'activité neuronale. Parmi ceux-ci les canaux SK constituent une cible thérapeutique intéressante car ils sous-tendent la posthyperpolarisation de durée moyenne qui limite l'excitabilité de divers types de neurones du système nerveux central. Une connaissance approfondie de la physiologie de ces canaux et la découverte de modulateurs non peptidiques sélectifs susceptibles de passer la barrière hémato-encéphaliques apparaissent donc indispensables dans la perspective de développer de futurs médicaments visant des maladies cérébrales telles que celles liées à un dysfonctionnement des sytèmes dopaminergiques et sérotoninergiques. [en] Various types of ion channels are involved in the control of neuronal activity. Among them, SK channels represent an interesting therapeutic target. Indeed, they underlie medium duration afterhyperpolarizations in many types of neurons, thus inhibiting cell excitability. A thorough knowledge of the physiology of these channels and the discovery of non-peptidic selective modulators able to pass the blood-brain barrier are essential in view of developing future drugs for brain diseases such as those related to a dysfunction of dopaminergic and serotonergic systems.
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