Article (Scientific journals)
Development of the Crohn's disease digestive damage score, the Lemann score.
Pariente, Benjamin; Cosnes, Jacques; Danese, Silvio et al.
2011In Inflammatory Bowel Diseases, 17 (6), p. 1415-22
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Keywords :
Colon/pathology/radiography/ultrasonography; Colonoscopy; Crohn Disease/pathology/radiography/ultrasonography; Disease Progression; Humans; Magnetic Resonance Imaging; Severity of Illness Index; Tomography, X-Ray Computed
Abstract :
[en] Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure disease activity at a specific point in time. An instrument to measure cumulative structural damage to the bowel, which may predict long-term disability, is needed. The aim of this article is to outline the methods to develop an instrument that can measure cumulative bowel damage. The project is being conducted by the International Program to develop New Indexes in Crohn's disease (IPNIC) group. This instrument, called the Crohn's Disease Digestive Damage Score (the Lemann score), should take into account damage location, severity, extent, progression, and reversibility, as measured by diagnostic imaging modalities and the history of surgical resection. It should not be "diagnostic modality driven": for each lesion and location, a modality appropriate for the anatomic site (for example: computed tomography or magnetic resonance imaging enterography, and colonoscopy) will be used. A total of 24 centers from 15 countries will be involved in a cross-sectional study, which will include up to 240 patients with stratification according to disease location and duration. At least 120 additional patients will be included in the study to validate the score. The Lemann score is expected to be able to portray a patient's disease course on a double-axis graph, with time as the x-axis, bowel damage severity as the y-axis, and the slope of the line connecting data points as a measure of disease progression. This instrument could be used to assess the effect of various medical therapies on the progression of bowel damage.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Pariente, Benjamin
Cosnes, Jacques
Danese, Silvio
Sandborn, William J
Lewin, Maite
Fletcher, Joel G
Chowers, Yehuda
D'Haens, Geert
Feagan, Brian G
Hibi, Toshifumi
Hommes, Daniel W
Irvine, E Jan
Kamm, Michael A
Loftus, Edward V Jr
Louis, Edouard  ;  Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Michetti, Pierre
Munkholm, Pia
Oresland, Tom
Panes, Julian
Peyrin-Biroulet, Laurent
Reinisch, Walter
Sands, Bruce E
Schoelmerich, Juergen
Schreiber, Stefan
Tilg, Herbert
Travis, Simon
van Assche, Gert
Vecchi, Maurizio
Mary, Jean*-Yves
Colombel, Jean*-Frederic
Lemann, Marc
More authors (21 more) Less
Language :
English
Title :
Development of the Crohn's disease digestive damage score, the Lemann score.
Publication date :
2011
Journal title :
Inflammatory Bowel Diseases
ISSN :
1078-0998
eISSN :
1536-4844
Publisher :
Lippincott Williams & Wilkins, Hagerstown, United States - Maryland
Volume :
17
Issue :
6
Pages :
1415-22
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2010 Crohn's & Colitis Foundation of America, Inc.
Available on ORBi :
since 16 January 2012

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