Article (Scientific journals)
Novel Susceptibility Locus at 22q11 for Diabetic Nephropathy in Type 1 Diabetes
Wessman, Maija; Forsblom, Carol; Kaunisto, Mari A et al.
2011In PLoS ONE, 9 (11), p. 24053
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Abstract :
[en] Background: Diabetic nephropathy (DN) affects about 30% of patients with type 1 diabetes (T1D) and contributes to serious morbidity and mortality. So far only the 3q21–q25 region has repeatedly been indicated as a susceptibility region for DN. The aim of this study was to search for new DN susceptibility loci in Finnish, Danish and French T1D families. Methods and Results: We performed a genome-wide linkage study using 384 microsatellite markers. A total of 175 T1D families were studied, of which 94 originated from Finland, 46 from Denmark and 35 from France. The whole sample set consisted of 556 individuals including 42 sib-pairs concordant and 84 sib-pairs discordant for DN. Two-point and multi-point non-parametric linkage analyses were performed using the Analyze package and the MERLIN software. A novel DN locus on 22q11 was identified in the joint analysis of the Finnish, Danish and French families by genome-wide multipoint nonparametric linkage analysis using the Kong and Cox linear model (NPLpairs LOD score 3.58). Nominal or suggestive evidence of linkage to this locus was also detected when the three populations were analyzed separately. Suggestive evidence of linkage was found to six additional loci in the Finnish and French sample sets. Conclusions: This study identified a novel DN locus at chromosome 22q11 with significant evidence of linkage to DN. Our results suggest that this locus may be of importance in European populations. In addition, this study supports previously indicated DN loci on 3q21–q25 and 19q13.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Wessman, Maija
Forsblom, Carol
Kaunisto, Mari A
So derlund, Jenny
Ilonen, Jorma
Sallinen, Riitta
Hiekkalinna, Tero
Parkkonen, Maija
Maxwell, Alexander P
Tarnow, Lise
Parving, Hans-Henrik
Hadjadj, Samy
Marre, Michel
Peltonen, Leena
SCHEEN, André  ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
FinnDiane Study Group
More authors (6 more) Less
Language :
English
Title :
Novel Susceptibility Locus at 22q11 for Diabetic Nephropathy in Type 1 Diabetes
Publication date :
2011
Journal title :
PLoS ONE
eISSN :
1932-6203
Publisher :
Public Library of Science, San Franscisco, United States - California
Volume :
9
Issue :
11
Pages :
e24053
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 January 2012

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