Reference : Surgical resection of a sphenoid wing meningioma in a patient with Glanzmann thrombasthe...

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Hematology Human health sciences : Surgery Human health sciences : Anesthesia & intensive care
	To cite this reference:	http://hdl.handle.net/2268/108020

Title :	Surgical resection of a sphenoid wing meningioma in a patient with Glanzmann thrombasthenia.
Language :	English
Author, co-author :	WERTZ, Damien [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation]
	Boveroux, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie biologique et immuno hématologie]
	PETERS, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Neurochirurgie]
	LENELLE, Jacques [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation]
	FRANSSEN, Colette [ > > ]
Publication date :	2011
Journal title :	Acta anaesthesiologica Belgica
Volume :	62
Issue/season :	2
Pages :	83-6
Audience :	International
ISSN :	0001-5164
Country :	Belgium
Keywords :	[en] Anticoagulants ; Factor VIIa/therapeutic use ; Female ; Hemostatics/therapeutic use ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Meningeal Neoplasms/complications/surgery ; Meningioma/complications/surgery ; Middle Aged ; Recombinant Proteins/therapeutic use ; Thrombasthenia/complications ; Treatment Outcome ; Venous Thrombosis/complications
Abstract :	[en] Glanzmann thrombasthenia (GT) is a rare autosomal recessive disorder characterized by a deficiency or functional defect of platelet glycoprotein (GP) IIb/IIIa. Physiologically, this platelet receptor mediates aggregation of activated platelets by binding the adhesive proteins, fibrinogen, von Willebrand factor (VWF) and fibronectin. This facilitates attachment and aggregation of platelets at sites of vascular injury. We reported the management of a pterional meningioma resection in a patient with Glanzmann thrombasthenia, with recombinant factor VIIa (rFVIIa - NovoSeven) as haemostatic agent. A 48-year-old woman suffering from Glanzmann thrombasthenia was scheduled for spheno-orbital meningioma en plaque surgery. Because of repeated platelet transfusions, this patient developed isoantibodies against missing GPIIbIIIa and alloantibodies against Human Leukocyte Antigen (HLA) leading to refractoriness to platelet transfusions. We observed that Novoseven offered sufficient haemostasis conditions. Therefore, we noticed a deep vein thrombosis. This imposed us to use low weight molecular heparin despite recent surgery.
Permalink :	http://hdl.handle.net/2268/108020

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