Reference : Surgical resection of a sphenoid wing meningioma in a patient with Glanzmann thrombas...
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
Human health sciences : Hematology
Human health sciences : Surgery
http://hdl.handle.net/2268/108020
Surgical resection of a sphenoid wing meningioma in a patient with Glanzmann thrombasthenia.
English
WERTZ, Damien mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation]
Boveroux, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie biologique et immuno hématologie]
PETERS, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurochirurgie]
LENELLE, Jacques mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation]
FRANSSEN, Colette mailto [ > > ]
2011
Acta anaesthesiologica Belgica
62
2
83-6
Yes (verified by ORBi)
International
0001-5164
Belgium
[en] Anticoagulants ; Factor VIIa/therapeutic use ; Female ; Hemostatics/therapeutic use ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Meningeal Neoplasms/complications/surgery ; Meningioma/complications/surgery ; Middle Aged ; Recombinant Proteins/therapeutic use ; Thrombasthenia/complications ; Treatment Outcome ; Venous Thrombosis/complications
[en] Glanzmann thrombasthenia (GT) is a rare autosomal recessive disorder characterized by a deficiency or functional defect of platelet glycoprotein (GP) IIb/IIIa. Physiologically, this platelet receptor mediates aggregation of activated platelets by binding the adhesive proteins, fibrinogen, von Willebrand factor (VWF) and fibronectin. This facilitates attachment and aggregation of platelets at sites of vascular injury. We reported the management of a pterional meningioma resection in a patient with Glanzmann thrombasthenia, with recombinant factor VIIa (rFVIIa - NovoSeven) as haemostatic agent. A 48-year-old woman suffering from Glanzmann thrombasthenia was scheduled for spheno-orbital meningioma en plaque surgery. Because of repeated platelet transfusions, this patient developed isoantibodies against missing GPIIbIIIa and alloantibodies against Human Leukocyte Antigen (HLA) leading to refractoriness to platelet transfusions. We observed that Novoseven offered sufficient haemostasis conditions. Therefore, we noticed a deep vein thrombosis. This imposed us to use low weight molecular heparin despite recent surgery.
http://hdl.handle.net/2268/108020

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