Reference : Preserved feedforward but impaired top-down processes in the vegetative state.
Scientific journals : Article
Human health sciences : Neurology
Preserved feedforward but impaired top-down processes in the vegetative state.
Boly, Mélanie mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie]
Garrido, Marta Isabel [> > > >]
Gosseries, Olivia mailto [Université de Liège - ULg > >]
Bruno, Marie-Aurélie mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
BOVEROUX, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation]
Schnakers, Caroline mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Massimini, Marcello [> > > >]
Litvak, Vladimir [> > > >]
Laureys, Steven mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Friston, Karl [> > > >]
American Association for the Advancement of Science
Yes (verified by ORBi)
[en] Adult ; Aged ; Aged, 80 and over ; Auditory Perception ; Awareness ; Bayes Theorem ; Brain Mapping ; Consciousness ; Electroencephalography ; Evoked Potentials, Auditory ; Female ; Frontal Lobe/physiology/physiopathology ; Humans ; Male ; Middle Aged ; Models, Neurological ; Models, Statistical ; Neural Pathways ; Parietal Lobe/physiology/physiopathology ; Persistent Vegetative State/diagnosis/physiopathology ; Reaction Time ; Temporal Lobe/physiology/physiopathology ; Young Adult
[en] Frontoparietal cortex is involved in the explicit processing (awareness) of stimuli. Frontoparietal activation has also been found in studies of subliminal stimulus processing. We hypothesized that an impairment of top-down processes, involved in recurrent neuronal message-passing and the generation of long-latency electrophysiological responses, might provide a more reliable correlate of consciousness in severely brain-damaged patients, than frontoparietal responses. We measured effective connectivity during a mismatch negativity paradigm and found that the only significant difference between patients in a vegetative state and controls was an impairment of backward connectivity from frontal to temporal cortices. This result emphasizes the importance of top-down projections in recurrent processing that involve high-order associative cortices for conscious perception.

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