Reference : Metabolic activity in external and internal awareness networks in severely brain-damaged...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/137556
Metabolic activity in external and internal awareness networks in severely brain-damaged patients.
English
Thibaut, Aurore mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Bruno, Marie-Aurélie mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Chatelle, Camille mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Gosseries, Olivia mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Vanhaudenhuyse, Audrey mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Demertzi, Athina mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Schnakers, Caroline mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Thonnard, Marie mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Charland, Vanessa [> >]
BERNARD, Claire mailto [Centre Hospitalier Universitaire de Liège - CHU > > Médecine nucléaire >]
Bahri, Mohamed Ali mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Phillips, Christophe mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Boly, Mélanie mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Hustinx, Roland mailto [Université de Liège - ULg > Département des sciences cliniques > Médecine nucléaire >]
Laureys, Steven mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
2012
Journal of Rehabilitation Medicine
Taylor & Francis
44
6
487-94
Yes (verified by ORBi)
International
1650-1977
Sweden
[en] vegetative state ; minimallys conscious state ; positron emission tomography ; consciousness ; self-awareness ; traumatic brain injury
[en] OBJECTIVE: An extrinsic cerebral network (encompassing lateral frontoparietal cortices) related to external/sensory awareness and an intrinsic midline network related to internal/self-awareness have been identified recently. This study measured brain metabolism in both networks in patients with severe brain damage. DESIGN: Prospective [18F]-fluorodeoxyglucose-positron emission tomography and Coma Recovery Scale-Revised assessments in a university hospital setting. SUBJECTS: Healthy volunteers and patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS), minimally conscious state (MCS), emergence from MCS (EMCS), and locked-in syndrome (LIS). RESULTS: A total of 70 patients were included in the study: 24 VS/UWS, 28 MCS, 10 EMCS, 8 LIS and 39 age-matched controls. VS/UWS showed metabolic dysfunction in extrinsic and intrinsic networks and thalami. MCS showed dysfunction mostly in intrinsic network and thalami. EMCS showed impairment in posterior cingulate/retrosplenial cortices. LIS showed dysfunction only in infratentorial regions. Coma Recovery Scale-Revised total scores correlated with metabolic activity in both extrinsic and part of the intrinsic network and thalami. CONCLUSION: Progressive recovery of extrinsic and intrinsic awareness network activity was observed in severely brain-damaged patients, ranging from VS/UWS, MCS, EMCS to LIS. The predominance of intrinsic network impairment in MCS could reflect altered internal/self-awareness in these patients, which is difficult to quantify at the bedside.
Coma Science Group, Cyclotron Research Centre, University of Liège
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/137556
also: http://hdl.handle.net/2268/107683
10.2340/16501977-0940

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