Reference : Potential anticancer activity of young Carpinus betulus leaves.
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/107482
Potential anticancer activity of young Carpinus betulus leaves.
English
Cieckiewicz, Ewa [Université de Liège - ULg > Département de pharmacie > Pharmacognosie]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie]
Gras, T. [> > > >]
Kiss, R. [> > > >]
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie]
15-Feb-2012
Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Urban & Fischer Verlag
19
3/4
278-284
Yes (verified by ORBi)
International
0944-7113
1618-095X
Stuttgart
Germany
[en] As part of our continuing research for anticancer compounds from the Walloon Region forest, EtOAc extract from Carpinus betulus leaves was phytochemically studied, leading to the bioguided isolation of pheophorbide a, which is responsible of anticancer properties of C. betulus young leaves. This compound was identified using nuclear magnetic resonance and mass spectrophotometric data and comparison with a commercial standard. Evaluation of the growth inhibitory activities of pheophorbide a using MTT colorimetric assay and phase-contrast microscopy in various human cancer cell lines confirmed the photoactivable properties of this compound. Our research showed, for the first time, the presence of pheophorbide a, a chlorophyll derived compound, which we quantified in high quantities in young leaves of C. betulus. This is in contrast with the literature which generally describes pheophorbide a as a catabolic product of chlorophyll, then preferentially present in old leaves.
http://hdl.handle.net/2268/107482
10.1016/j.phymed.2011.09.072
Copyright (c) 2011 Elsevier GmbH. All rights reserved.

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