Article (Scientific journals)
Potential anticancer activity of young Carpinus betulus leaves.
Cieckiewicz, Ewa; Angenot, Luc; Gras, T. et al.
2012In Phytomedicine, 19 (3/4), p. 278-284
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Abstract :
[en] As part of our continuing research for anticancer compounds from the Walloon Region forest, EtOAc extract from Carpinus betulus leaves was phytochemically studied, leading to the bioguided isolation of pheophorbide a, which is responsible of anticancer properties of C. betulus young leaves. This compound was identified using nuclear magnetic resonance and mass spectrophotometric data and comparison with a commercial standard. Evaluation of the growth inhibitory activities of pheophorbide a using MTT colorimetric assay and phase-contrast microscopy in various human cancer cell lines confirmed the photoactivable properties of this compound. Our research showed, for the first time, the presence of pheophorbide a, a chlorophyll derived compound, which we quantified in high quantities in young leaves of C. betulus. This is in contrast with the literature which generally describes pheophorbide a as a catabolic product of chlorophyll, then preferentially present in old leaves.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Cieckiewicz, Ewa ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Gras, T.
Kiss, R.
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Potential anticancer activity of young Carpinus betulus leaves.
Publication date :
15 February 2012
Journal title :
Phytomedicine
ISSN :
0944-7113
eISSN :
1618-095X
Publisher :
Urban & Fischer Verlag, Stuttgart, Germany
Volume :
19
Issue :
3/4
Pages :
278-284
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2011 Elsevier GmbH. All rights reserved.
Available on ORBi :
since 11 January 2012

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