Reference : IL28B polymorphism and the control of hepatitis C virus infection: ready for clinical use?
Scientific journals : Article
Life sciences : Genetics & genetic processes
Human health sciences : Gastroenterology & hepatology
http://hdl.handle.net/2268/107175
IL28B polymorphism and the control of hepatitis C virus infection: ready for clinical use?
English
Orlent, Hans [> > > >]
Reynaert, Hendrik [> > > >]
Bourgeois, Stefan [> > > >]
DIDEBERG, Vinciane mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique]
Adler, Michael [> > > >]
Colle, Isabelle [> > > >]
De Maeght, Stephane [> > > >]
Laleman, Wim [> > > >]
Michielsen, Peter [> > > >]
Moreno, Christophe [> > > >]
Mulkay, Jean-Pierre [> > > >]
Starkel, Peter [> > > >]
DELWAIDE, Jean mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gastro-Entérologie-Hépatologie >]
2011
Acta Gastro-Enterologica Belgica
Acta Medica Belgica
74
2
317-322
Yes (verified by ORBi)
International
0001-5644
Bruxelles
Belgique
[en] Antiviral Agents/therapeutic use ; DNA/genetics ; Genotype ; Hepacivirus/genetics ; Hepatitis C/drug therapy/genetics/metabolism ; Humans ; Interleukins/genetics/metabolism ; Polymorphism, Genetic
[en] Polymorphisms in the region of the interleukin-28B (IL28B) gene have recently been associated with spontaneous and treatment induced clearance of hepatitis C virus infection. The specific mechanisms of how IL28B polymorphisms affect HCV suppression remain unknown. It is a matter of ongoing debate how to incorporate the IL28B data into the current treatment algorithms with pegylated interferon-alpha and ribavirin. The eventual role of the IL28B genotype in new therapeutic regimes with direct antiviral agents needs to be explored in the ongoing and future clinical studies with these agents.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/107175
also: http://hdl.handle.net/2268/110114

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