Article (Scientific journals)
Muscle fatigue experienced during maximal eccentric exercise is predictive of the plasma creatine kinase (CK) response
Hody, Stéphanie; Rogister, Bernard; Leprince, Pierre et al.
2013In Scandinavian Journal of Medicine and Science in Sports, 23 (4), p. 501-7
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Keywords :
creatine kinase activity; muscle fatigue; muscular work; muscle damage; eccentric contraction
Abstract :
[en] Unaccustomed eccentric exercise may cause skeletal muscle damage with an increase in plasma creatine kinase (CK) activity. Although the wide variability among individuals in CK response to standardized lengthening contractions has been well described, the reasons underlying this phenomenon have not yet been understood. Therefore, this study investigated a possible correlation of the changes in muscle damage indirect markers after an eccentric exercise with the decline in muscle performance during the exercise. Twenty-seven healthy untrained male subjects performed three sets of 30 maximal isokinetic eccentric contractions of the knee extensors. The muscular work was recorded using an isokinetic dynamometer to assess muscle fatigue by means of various fatigue indices. Plasma CK activity, muscle soreness, and stiffness were measured before (pre) and one day after (post) exercise. The eccentric exercise bout induced significant changes of the three muscle damage indirect markers. Large intersubject variability was observed for all criteria measured. More interestingly, the log (CKpost/CKpre) and muscle stiffness appeared to be closely correlated with the relative work decrease (r = 0.84, r2 = 0.70 and r = 0.75, r2 = 0.56, respectively). This is the first study to propose that the muscle fatigue profile during maximal eccentric protocol could predict the magnitude of the symptoms associated with muscle damage in humans.
Research center :
Giga-Neurosciences - ULiège
Département de Médecine Physique
Département des Sciences de la Motricité
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Hody, Stéphanie ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Rogister, Bernard  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Leprince, Pierre ;  Université de Liège - ULiège > GIGA - Neurosciences
WANG, François-Charles  ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
CROISIER, Jean-Louis ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
Language :
English
Title :
Muscle fatigue experienced during maximal eccentric exercise is predictive of the plasma creatine kinase (CK) response
Publication date :
August 2013
Journal title :
Scandinavian Journal of Medicine and Science in Sports
ISSN :
0905-7188
eISSN :
1600-0838
Publisher :
Munksgaard International Publishers, Copenhagen, Denmark
Volume :
23
Issue :
4
Pages :
501-7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 January 2012

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