Reference : The Audiospinal Reaction in Parkinsonian Patients Reflects Functional Changes in Reti...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/106640
The Audiospinal Reaction in Parkinsonian Patients Reflects Functional Changes in Reticular Nuclei
English
Delwaide, Paul [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
PEPIN, Jean-Louis mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR >]
Maertens De Noordhout, Alain mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR >]
1993
Annals of Neurology
Wiley Liss
33
1
63-9
Yes (verified by ORBi)
International
0364-5134
1531-8249
New York
NY
[en] Acoustic Stimulation ; Aged ; Electromyography ; Female ; H-Reflex ; Habituation, Psychophysiologic ; Humans ; Levodopa/therapeutic use ; Male ; Middle Aged ; Parkinson Disease/drug therapy/physiopathology ; Reference Values ; Reticular Formation/physiopathology
[en] Audiospinal facilitation using the soleus H-reflex as a test was compared in 16 control subjects and 23 parkinsonian patients. In the patients, facilitation was significantly reduced during the 75 to 150 msec after the conditioning stimulation. This reduction was seen bilaterally even in patients with a hemisyndrome. It was corrected by L-dopa but not by anticholinergic agents. Facilitation at the 75-msec delay showed an inverse linear correlation with the bradykinesia intensity (r = -0.7, p < 0.01). The results argue in favor of a reduced excitability of the nucleus reticularis pontis caudalis from which a reticulospinal tract emanates as effector of the audiospinal facilitation. This would represent another example of dysfunction of reticular nuclei in Parkinson's disease.
Researchers ; Professionals
http://hdl.handle.net/2268/106640
10.1002/ana.410330111

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