Apoptosis; Autophagy; Humans; Leg Ulcer/pathology; Male; Middle Aged; Necrosis
Abstract :
[en] The medical history of a leg ulcer is spangled with episodes contributing to its chronicity before leading to possible healing. The complexity of the involved biological factors is undisputable. In order to simplify the management of these lesions, some doctors and nurses summarize the evolution of a leg ulcer in 3 phases according to the colour of the wound bed: black, yellow and red. The latter stage is commonly considered as a favourable condition for skin healing. We criticize such a concept by showing the anatomo-functional heterogeneity of the red wound bed.
Disciplines :
Dermatology
Author, co-author :
HENRY, Frédérique ; Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
QUATRESOOZ, Pascale ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Stevens NM, Shultz T, Mizner RL, et al. - Treatment in an outpatient setting for a patient with an infected, surgical wound with hypergranulation tissue. Int J Low Extrm Wounds, 2009, 8, 37-44.
Piérard GE, Piérard-Franchimont C, Lapière Ch M. - Proliferation and hyperplasia of vascular endothelium in human skin. Am J Dermatopathol, 1985, 7, 477-488.
Quatresooz P, Henry F, Paquet P, et al. - Deciphering the impaired cytokine cascades in chronic leg ulcers. Int J Mol Med, 2003, 11, 411-418.
Paquet P, Jacob E, Quatresooz P, et al. - Delayed reepithelialization and scarring deregulation following drug-induced toxic epidermal necrolysis. Burns, 2007, 33, 100-104.
Hsieh YC, Athar M, Chaudry IH. - When apoptosis meets autophagy : deciding cell fate after trauma and sepsis. Trends Mol Med, 2009, 15, 129-138.
Lippens S, Hoste E, Vandenabeele P, et al. - Cell death in the skin. Apoptosis, 2009, 14, 283-284.
Dereure O. - L'apoptose en dermatologie. Ann Dermatol Venereol, 2000, 127, 432-441.
Paquet P, Piérard GE. - Toxic epidermal necrolysis : revisiting the tentative link between early apoptosis and late necrosis. Int J Mol Med, 2007, 19, 3-10.
Levine B, Kremer G. - Autophagy in the pathogenesis of disease. Cell, 2008, 132, 27-42.
Scarlatti F, Granata R, Meijer AJ, et al. - Does autophagy have a licence to kill mammalian cells ? Cell Death Differ, 2009, 16, 12-20.
Berardesca E, Lévêque JL, Masson P, et al. - EEMCO guidance for the measurement of skin microcirculation. Skin Pharmacol Appl Skin Physiol, 2002, 15, 442-456.
Piérard-Franchimont C, Paquet P, Arrese JE, et al. - Healing rate and bacterial necrotizing vasculitis in venous leg ulcers. Dermatology, 1997, 194, 383-387.
Atiyeh BS, Hayek SN. - The safety and efficacy of dressings with silver - addressing clinical concerns. Int Wound J, 2007, 4, 283-284.
Chaby G, Senet P, Vaneau M, et al. - Dressings for acute and chronic wounds : a systematic review. Arch Dermatol, 2007, 143, 1297-1304. (Pubitemid 47607683)
Moore RA, Liedl DA, Jenkins S, et al. - Using a silver-coated polymeric substrate for the management of chronic ulcerations : the initial Mayo Clinic experience. Adv Skin Wound Care, 2008, 21, 517-520.
Sibbald RG, Contreras-Ruiz J, Coutts P, et al. - Bacteriology, inflammation and healing : a study of nanocrystalline silver dressing in chronic venous leg ulcers. Adv Skin Wound Care, 2007, 20, 549-558.
Quatresooz P, Paquet P, Piérard-Franchimont C, et al. - Rôle de la povidone iodée dans la cicatrisation des ulcères chroniques de jambe. J Plaies Cicat, 2005, 10, 7-10.
Paquet P, Quatresooz P, Braham C, et al. - Tapping into the influence of keratinocyte allografts and biocenosis on healing of chronic leg ulcers : split-ulcer controlled pilot study. Dermatol Surg, 2005, 31, 431-435. (Pubitemid 40489304)
Bourguignon R, Paquet P, Piérard-Franchimont C, et al. - Treatment of pyogenic granulomas with the Nd-Yag laser. J Dermatol Treat, 2006, 17, 247-249. (Pubitemid 44395555)
