Reference : Smouldering malignant melanoma and metastatic dormancy: an update and review.
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
http://hdl.handle.net/2268/106330
Smouldering malignant melanoma and metastatic dormancy: an update and review.
English
PIERARD, Gérald mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
PIERARD-FRANCHIMONT, Claudine [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
REGINSTER, Marie-Annick mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
QUATRESOOZ, Pascale mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
2012
Dermatology Research and Practice
2012
461278
Yes (verified by ORBi)
International
1687-6105
1687-6113
Egypt
[en] The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete. The recent literature pertaining to the current understanding of the mechanisms underlying two special features of MM metastasis is reviewed. On the one hand, a long disease-free interval (MM dormancy) may occur before the surge of overt metastases. On the other hand, the so-called MM smouldering phenomenon refers to the condition where regional metastases wax and wane for long periods of time on restricted skin regions. It is important to emphasize that local micrometastases often predict sentinel lymph node involvement but may not reflect progression of the primary MM to full-blown visceral metastatic competence. It is likely that a combination of factors impacts the versatile MM metastasic progression. Among the main factors, one has to mention the phenotypic heterogeneity and variability in the phenotype of MM cells, the presence of MM stem cells and MM cells engaged in an amplification proliferation pool, as well as the host immune response, and possibly the induction of a particular stromal structure and vascularity.
http://hdl.handle.net/2268/106330
10.1155/2012/461278

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Smouldering MM.pdfPublisher postprint295.55 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.