Article (Scientific journals)
Hypomelanosis of Ito: pigmentary mosaicism with immature melanosome in keratinocytes.
Devillers, Céline; QUATRESOOZ, Pascale; Hermanns-Lê, Trinh et al.
2011In International Journal of Dermatology, 50 (10), p. 1234-9
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Abstract :
[en] BACKGROUND: Hypomelanosis of Ito is a rare genetic disorder characterized by whorled areas of hypomelanosis. The purpose of the present study was to revisit some aspects of Ito's hypomelanosis. METHODS: Clinical observations included ultraviolet-light-enhanced visualization (ULEV) method. Histochemistry, immunohistochemistry, and electron microscopy were performed on biopsy samples from the hypopigmented areas and the surrounding skin. RESULTS: Both the ULEV and microscopic examinations revealed the heterogeneity of the pigmentation. Hypomelanosis was characterized by a reduction in melanosomes, both in melanocytes and keratinocytes. These organelles were immature and atypical, showing a weak tyrosinase immunoreactivity. Melanosome macroautophagy was prominent in keratinocytes. Some clusters of the same cells exhibited strong immunoreactivity for the Mac 387 antibody (Ca(2+) -dependent calprotectin). Ulex europaeus agglutinin-1 (UEA-1) decorated the superficial layers of the epidermis. Such features are typically found in functionally altered keratinocytes. A number of dermal cells exhibited intense phagocytic activity linked to lysozyme immunoreactivity. CONCLUSIONS: Both the melanosome depletion and macroautophagy of immature melanosomes in keratinocytes appeared to represent prominent aspects of hypomelanosis of Ito. In sum, Ito's hypomelanosis combines structural and functional changes affecting both the melanocytes and keratinocytes in the skin.
Disciplines :
Dermatology
Author, co-author :
Devillers, Céline
QUATRESOOZ, Pascale  ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Hermanns-Lê, Trinh ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Szepetiuk, Gregory
Lemaire, Roland
PIERARD-FRANCHIMONT, Claudine ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
PIERARD, Gérald ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
English
Title :
Hypomelanosis of Ito: pigmentary mosaicism with immature melanosome in keratinocytes.
Publication date :
2011
Journal title :
International Journal of Dermatology
ISSN :
0011-9059
eISSN :
1365-4362
Publisher :
Decker Periodicals, Lewiston, United States - New York
Volume :
50
Issue :
10
Pages :
1234-9
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2011 The International Society of Dermatology.
Available on ORBi :
since 27 December 2011

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