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Etude clinique du mois. Protection secondaire de l'accident vasculaire cerebral par le perindopril: l'etude PROGRESS.
Scheen, André
2001In Revue Médicale de Liège, 56 (11), p. 792-5
Peer reviewed
 

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Keywords :
Angiotensin-Converting Enzyme Inhibitors/pharmacology/therapeutic use; Clinical Trials as Topic; Diuretics/pharmacology/therapeutic use; Humans; Hypertension/complications; Indapamide/pharmacology/therapeutic use; International Cooperation; Multicenter Studies as Topic; Perindopril/pharmacology/therapeutic use; Preventive Medicine; Randomized Controlled Trials as Topic; Risk Factors; Stroke/etiology/prevention & control
Abstract :
[en] PROGRESS ("Perindopril pROtection aGainst REcurrent Stroke Study") demonstrated that blood-pressure lowering treatment with perindopril, an angiotensin converting enzyme inhibitor (combined with the diuretic agent indapamide when necessary), reduces the risk of stroke by 28% (95% CI: 17-38, p < 0.0001) among patients with a history of stroke or transient ischaemic attack. This protective effect was observed among both hypertensive and non-hypertensive individuals. It was more marked in the patients receiving combined perindopril + indapamide treatment (-43%; 95% CI 30-54) who were those who showed the greatest reduction in arterial blood pressure (-12/5 mm Hg). According to these observations, the authors concluded that treatment with these two agents should now be considered routinely for patients with a history of stroke or transient ischaemic attack, irrespective of their blood pressure.
Disciplines :
Pharmacy, pharmacology & toxicology
Cardiovascular & respiratory systems
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
Etude clinique du mois. Protection secondaire de l'accident vasculaire cerebral par le perindopril: l'etude PROGRESS.
Alternative titles :
[en] Clinical study of the month. Secondary prevention of cerebrovascular accident with perindopril: the PROGRESS study
Publication date :
2001
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
56
Issue :
11
Pages :
792-5
Peer reviewed :
Peer reviewed
Additional URL :
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