Reference : Prostaglandin E2, prostacyclin, and thromboxane changes during nonpulsatile cardiopulmon...
Scientific journals : Article
Human health sciences : Surgery
Human health sciences : Anesthesia & intensive care
http://hdl.handle.net/2268/10603
Prostaglandin E2, prostacyclin, and thromboxane changes during nonpulsatile cardiopulmonary bypass in humans.
English
Faymonville, Marie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Deby, Ginette [Université de Liège - ULg > > Centre de l'oxygène : Recherche et développement (C.O.R.D.) >]
Larbuisson, Robert mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Deby, C. [ > > ]
Bodson, Lucien mailto [Centre Hospitalier Universitaire de Liège - CHU > > Urgences >]
Limet, Raymond mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Lamy, Maurice mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
1986
Journal of Thoracic and Cardiovascular Surgery (The)
Mosby
91
6
858-66
Yes (verified by ORBi)
International
0022-5223
1097-685X
St Louis
MO
[en] 6-Ketoprostaglandin F1 alpha/blood ; Aged ; Cardiopulmonary Bypass ; Coronary Artery Bypass ; Dinoprostone ; Epoprostenol/blood ; Heart-Lung Machine ; Humans ; Lung/metabolism ; Middle Aged ; Orthopedics ; Prostaglandins E/blood/metabolism ; Thromboxane A2/blood ; Thromboxane B2/blood
[en] To study the effect of lung bypass on the production of prostaglandin E2, prostacyclin, and thromboxane A2, we measured simultaneously arterial and venous plasma concentrations of prostaglandin E2, 6-keto-prostaglandin F1 alpha (stable metabolite of prostacyclin), and thromboxane B2 (stable metabolite of thromboxane A2) before, during, and after cardiopulmonary bypass. Seventeen patients (age range 46 to 69 years) undergoing aorta-coronary bypass grafts were investigated. The prostaglandin E2 production rose sharply immediately after the onset of bypass (baseline: 9.7 +/- 2.9 pg/ml to 85 +/- 16.6 pg/ml in venous and 87 +/- 12 pg/ml in arterial plasma, p less than 0.03) and rapidly decreased after pulmonary reperfusion (53 +/- 6.4 and 57 +/- 20 pg/ml, respectively, in venous and arterial plasma at the end of bypass). The increase in prostaglandin E2 was influenced by the heart-lung machine itself (as demonstrated by a closed "bypass" circuit) and by lung bypass. Pulmonary metabolism of prostaglandin E2 was maintained after bypass. The prostacyclin production rose significantly at the beginning of bypass (154 +/- 26 pg/ml venous prebypass level to 361 +/- 94 pg/ml after aortic clamping, p less than 0.03). Prostacyclin decreased progressively during rewarming of the patient, pulmonary reperfusion, and discontinuation of bypass. When prostacyclin decreased, thromboxane B2 production rose significantly and reached peak arterial levels when the lungs were reperfused (112 +/- 33 pg/ml prebypass levels to 402 +/- 101 pg/ml, p less than 0.01). Except for prostaglandin E2, there were no significant differences between arterial and venous plasma levels of these substances. The same prostanoids were also measured in five patients undergoing major orthopedic operations, and no significant changes in prostanoids were observed. Our data demonstrate significant production of prostaglandin E2 in the systemic circulation during cardiopulmonary bypass in humans. They further indicate that lung bypass disturbs the plasma prostaglandin/thromboxane balance.
http://hdl.handle.net/2268/10603

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