Reference : Novel amphiphilic mikto-arm star-shaped copolymers for the preparation of PLA-based nano...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/106025
Novel amphiphilic mikto-arm star-shaped copolymers for the preparation of PLA-based nanocarriers
English
Cajot, Sébastien [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Riva, Raphaël [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Billiet, Leen [University of Ghent > Department of Organic Chemistry > Polymer Chemistry Research Group (PCR) > >]
Du Prez, Filip [University of Ghent > Department of Organic Chemistry > Polymer Chemistry Research Group (PCR) > >]
Alexandre, Michaël mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Lecomte, Philippe mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Dec-2011
Macromolecular Symposia
Wiley
309/310
1
111-122
Yes (verified by ORBi)
International
1022-1360
1521-3900
Germany
[en] ring-opening polymerization (ROP) ; lactone ; click chemistry ; copper-mediated Huisgen's cycloaddition ; star-shaped polymer ; organic nanoparticle ; polymer functionalization
[en] Three-arm (A2B) and four-arm (A2B2) star-shaped copolymers based on biocompatible and biodegradable hydrophobic poly(ε-caprolactone) (PCL) (A arms) and biocompatible and bioeliminable hydrophilic poly(ethylene oxide) (PEO) (B arms) were synthesized by the coupling of an ω-azide terminated PEO chains with PCL chain bearing one (A2B) or two (A2B2) alkyne functions at the middle of the chain by the copper mediated azide-alkyne cycloaddition (CuAAC). The amphiphilic behavior of these different stars was confirmed by micellization experiments in water followed by dynamic light scattering and transmission electron microscopy analyses. The efficiency to stabilize PLA nanoparticles was investigated in function of the stars structure.
Center for Education and Research on Macromolecules (CERM)
Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The Walloon Region in the frame of the EMULFIVE project
Researchers
http://hdl.handle.net/2268/106025
10.1002/masy.201100044
http://onlinelibrary.wiley.com/doi/10.1002/masy.201100044/pdf

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