ORBi: Cajot Sébastien - Novel amphiphilic mikto-arm star-shaped copolymers for the preparation of PLA-based nanocarriers

Reference : Novel amphiphilic mikto-arm star-shaped copolymers for the preparation of PLA-based nano...


	Document type :	Scientific journals : Article
	Discipline(s) :	Engineering, computing & technology : Materials science & engineering Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/106025

Title :	Novel amphiphilic mikto-arm star-shaped copolymers for the preparation of PLA-based nanocarriers
Language :	English
Author, co-author :	Cajot, Sébastien [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Riva, Raphaël [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Billiet, Leen [University of Ghent > Department of Organic Chemistry > Polymer Chemistry Research Group (PCR) > >]
	Du Prez, Filip [University of Ghent > Department of Organic Chemistry > Polymer Chemistry Research Group (PCR) > >]
	Alexandre, Michaël [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Lecomte, Philippe [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Jérôme, Christine [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Publication date :	Dec-2011
Journal title :	Macromolecular Symposia
Publisher :	Wiley
Volume :	309/310
Issue/season :	1
Pages :	111-122
Audience :	International
ISSN :	1022-1360
e-ISSN :	1521-3900
Country :	Germany
Keywords :	[en] ring-opening polymerization (ROP) ; lactone ; click chemistry ; copper-mediated Huisgen's cycloaddition ; star-shaped polymer ; organic nanoparticle ; polymer functionalization
Abstract :	[en] Three-arm (A2B) and four-arm (A2B2) star-shaped copolymers based on biocompatible and biodegradable hydrophobic poly(ε-caprolactone) (PCL) (A arms) and biocompatible and bioeliminable hydrophilic poly(ethylene oxide) (PEO) (B arms) were synthesized by the coupling of an ω-azide terminated PEO chains with PCL chain bearing one (A2B) or two (A2B2) alkyne functions at the middle of the chain by the copper mediated azide-alkyne cycloaddition (CuAAC). The amphiphilic behavior of these different stars was confirmed by micellization experiments in water followed by dynamic light scattering and transmission electron microscopy analyses. The efficiency to stabilize PLA nanoparticles was investigated in function of the stars structure.
Research units :	Center for Education and Research on Macromolecules (CERM)
Funders :	Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The Walloon Region in the frame of the EMULFIVE project
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/106025
DOI :	10.1002/masy.201100044
Other URL :	http://onlinelibrary.wiley.com/doi/10.1002/masy.201100044/pdf

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