Reference : Biochemical investigations after burning injury: complement system, protease-antiproteas...
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
Human health sciences : Anesthesia & intensive care
http://hdl.handle.net/2268/10602
Biochemical investigations after burning injury: complement system, protease-antiprotease balance and acute-phase reactants.
English
Faymonville, Marie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Micheels, Jean mailto [Université de Liège - ULg > Département des sciences de la santé publique > Département des sciences de la santé publique >]
Bodson, Lucien mailto [Centre Hospitalier Universitaire de Liège - CHU > > Urgences >]
Jacquemin, Denise mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie maxillo-faciale et plastique >]
Lamy, Maurice mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Adam, J. [> > > >]
Duchateau, J. [> > > >]
1987
Burns
Elsevier
13
1
26-33
Yes (verified by ORBi)
International
0305-4179
New York
NY
[en] Acute-Phase Proteins/blood ; Adult ; Blood Proteins ; Burns/blood/enzymology/immunology ; C-Reactive Protein/analysis ; Complement Activation ; Complement C3/analysis ; Complement C3d ; Complement C5/analysis ; Complement C5a ; Complement System Proteins/analysis ; Female ; Humans ; Leukocytes/enzymology ; Male ; Middle Aged ; Pancreatic Elastase/blood ; Peptide Hydrolases/blood ; Prospective Studies ; Protease Inhibitors/blood ; alpha 1-Antitrypsin ; alpha-Macroglobulins/analysis
[en] Seventeen burned patients were investigated--Group I (n=10) with a mean burned area expressed as unit burn standard (UBS) of 69 +/- 24 and Group II (n = 7) with a mean UBS of 23 +/- 8. Blood samples were collected immediately after admission, 6-12 h after injury, during the morning and evening of day 1, and then daily for 2 weeks. This prospective study demonstrated complement activation in vivo in all burned patients, measured by C3d/C3 ratio index which was not related to the extent of the burned surface. A significant protease-antiprotease imbalance, correlated to the severity of burns, was found, leukocyte elastase was increased throughout the observation period, alpha 2-macroglobulin drastically decreased in severely burned patients, and alpha 1-proteinase inhibitor promptly decreased below the normal level in patients with more than 40 UBS. Finally, there was a delayed but then persistent acute-phase reactant protein response involving C-reactive protein, haptoglobin and alpha 1-acid glycoprotein, the concentrations of which reached a plateau on days 6 or 7.
http://hdl.handle.net/2268/10602

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