Article (Scientific journals)
L'etude clinique du mois. L'etude LIFE: protection cardio-vasculaire du patient hypertendu par le losartan.
Scheen, André
2002In Revue Médicale de Liège, 57 (4), p. 240-4
Peer reviewed
 

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Keywords :
Aged; Antihypertensive Agents/pharmacology; Atenolol/pharmacology; Clinical Trials as Topic; Endpoint Determination; Female; Humans; Hypertension/complications/drug therapy; Losartan/pharmacology; Male; Myocardial Infarction/etiology/prevention & control; Stroke/etiology/prevention & control; Treatment Outcome
Abstract :
[en] The LIFE study ("Losartan Intervention For Endpoint reduction in hypertension study") demonstrated a significant cardiovascular protection by an angiotensin AT1 receptor antagonist, losartan, in hypertensive patients with left ventricular hypertrophy. At similar blood pressure control, losartan, as compared to atenolol, reduced the relative risk of primary cardiovascular event (death, myocardial infarction, or stroke) by 13% (p = 0.021) in the whole cohort of 9.193 patients after a mean follow-up of 4.7 years. In a subgroup of 1.195 diabetic patients, the protection was even more marked with a reduction of the combined risk of 24% (p = 0.031) and a fall of the mortality of 39% (p = 0.002). In conclusion, losartan prevents cardiovascular morbidity and death more effectively than atenolol, and seems to confer benefits beyond reduction in blood pressure.
Disciplines :
Pharmacy, pharmacology & toxicology
Cardiovascular & respiratory systems
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
L'etude clinique du mois. L'etude LIFE: protection cardio-vasculaire du patient hypertendu par le losartan.
Alternative titles :
[en] Clinical study of the month. The LIFE study: cardiovascular protection of hypertensive patients by losartan
Publication date :
2002
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
57
Issue :
4
Pages :
240-4
Peer reviewed :
Peer reviewed
Additional URL :
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