Article (Scientific journals)
Reduced cell turnover in lymphocytic monkeys infected by human T-lymphotropic virus type 1.
Debacq, Christophe; Heraud, Jean-Michel; Asquith, Becca et al.
2005In Oncogene, 24 (51), p. 7514-23
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Keywords :
Animals; Antimetabolites/diagnostic use; Bromodeoxyuridine/diagnostic use; CD4-Positive T-Lymphocytes/physiology/virology; Cell Proliferation; Disease Models, Animal; HTLV-I Infections/immunology/physiopathology; Human T-lymphotropic virus 1; Leukemia/virology; Lymphocyte Count; Male; Saimiri
Abstract :
[en] Understanding cell dynamics in animal models have implications for therapeutic strategies elaborated against leukemia in human. Quantification of the cell turnover in closely related primate systems is particularly important for rare and aggressive forms of human cancers, such as adult T-cell leukemia. For this purpose, we have measured the death and proliferation rates of the CD4+ T lymphocyte population in squirrel monkeys (Saimiri sciureus) infected by human T-lymphotropic virus type 1 (HTLV-1). The kinetics of in vivo bromodeoxyuridine labeling revealed no modulation of the cell turnover in HTLV-1-infected monkeys with normal CD4 cell counts. In contrast, a substantial decrease in the proliferation rate of the CD4+ T population was observed in lymphocytic monkeys (e.g. characterized by excessive proportions of CD4+ T lymphocytes and by the presence of abnormal flower-like cells). Unexpectedly, onset of HTLV-associated leukemia thus occurs in the absence of increased CD4+ T-cell proliferation. This dynamics significantly differs from the generalized activation of the T-cell turnover induced by other primate lymphotropic viruses like HIV and SIV.
Disciplines :
Oncology
Author, co-author :
Debacq, Christophe
Heraud, Jean-Michel
Asquith, Becca
Bangham, Charles
Merien, Fabrice
Moules, Vincent
Mortreux, Franck
Wattel, Eric
Burny, Arsène ;  Université de Liège - ULiège > Agro Biotech Gembloux
Kettmann, Richard ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Kazanji, Mirdad
Willems, Luc  ;  Université de Liège - ULiège > GIGA-Research
Language :
English
Title :
Reduced cell turnover in lymphocytic monkeys infected by human T-lymphotropic virus type 1.
Publication date :
2005
Journal title :
Oncogene
ISSN :
0950-9232
eISSN :
1476-5594
Publisher :
Nature Publishing Group, Basingstoke, United Kingdom
Volume :
24
Issue :
51
Pages :
7514-23
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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