Article (Scientific journals)
L'etude clinique du mois. L'etude EUROPA: protection cardio-vasculaire avec le perindopril chez les patients avec coronaropathie stable.
Scheen, André; Legrand, Victor
2003In Revue Médicale de Liège, 58 (11), p. 713-6
Peer reviewed
 

Files


Full Text
200311_13.pdf
Publisher postprint (447.14 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Coronary Artery Disease/complications; Double-Blind Method; Female; Heart Arrest/etiology/prevention & control; Humans; Male; Middle Aged; Myocardial Infarction/etiology/prevention & control; Perindopril/therapeutic use; Placebos; Risk Factors; Treatment Outcome
Abstract :
[en] The multicentre placebo-controlled double-blind "EUropean trial on Reduction Of cardiac events with Perindopril in patients with stable coronary Artery disease" (EUROPA) assessed whether the angiotensin-converting-enzyme inhibitor perindopril reduces cardiovascular risk in a population with stable coronary heart disease and no apparent heart failure, whatever the associated cardiovascular risk. Patients were randomly assigned perindopril 8 mg once daily (n = 6110) or matching placebo (n = 6108). After a mean follow-up of 4.2 years, a relative risk reduction of 20% (95% CI 9-29, p = 0.0003) was observed in the combined primary endpoint (cardiovascular death, myocardial infarction, or cardiac arrest) in the group treated with perindopril as compared to placebo. About 50 patients needed to be treated for a period of 4 years to prevent one major cardiovascular event. This benefit was consistent in all predefined subgroups. According to these results, treatment with perindopril, on top of other preventive medications, should be considered in all patients with stable coronary heart disease.
Disciplines :
Cardiovascular & respiratory systems
Pharmacy, pharmacology & toxicology
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Legrand, Victor ;  Centre Hospitalier Universitaire de Liège - CHU > Cardiologie
Language :
French
Title :
L'etude clinique du mois. L'etude EUROPA: protection cardio-vasculaire avec le perindopril chez les patients avec coronaropathie stable.
Alternative titles :
[en] Clinical study of the month. The EUROPA study: cardiovascular protection with perindopril in patients with stable coronary heart disease
Publication date :
2003
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
58
Issue :
11
Pages :
713-6
Peer reviewed :
Peer reviewed
Additional URL :
Available on ORBi :
since 08 April 2009

Statistics


Number of views
411 (1 by ULiège)
Number of downloads
313 (1 by ULiège)

Bibliography


Similar publications



Contact ORBi