Article (Scientific journals)
Angioplastie percutanee coronaire chez le patient diabetique. Partie 3: Nouvelles perspectives apportees par les stents enrobes.
Warzee, Fabian; Legrand, Victor; Scheen, André
2004In Revue Médicale de Liège, 59 (12), p. 711-6
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Keywords :
Angioplasty, Transluminal, Percutaneous Coronary/instrumentation; Coronary Disease/therapy; Coronary Restenosis/prevention & control; Diabetes Complications/therapy; Drug Delivery Systems; Humans; Paclitaxel/therapeutic use; Platelet Aggregation Inhibitors/therapeutic use; Sirolimus/therapeutic use; Stents
Abstract :
[en] Coronary revascularization procedures are associated with less favourable outcomes in diabetic patients as compared to non-diabetic individuals. Especially, percutaneous coronary angioplasty (PTCA) is associated with a high level of restenosis and recurrent cardiac morbidity and mortality. In diabetic patients, PTCA should ideally be combined with stents. Bare-metal stents reduce by almost half the risk of restenosis, but this favourable effect decreases with the vessel calibre, a common finding in diabetic patients. Drug-eluting stents containing pharmacological agents that can reduce the risk of restenosis (sirolimus, paclitaxel) provide better angiographic results, including in small coronary arteries, and this effect has been shown to be accompanied by significant reduction of both morbidity and mortality. Such preliminary results obtained in the general population (including around 20% of diabetic subjects) deserve further confirmation in a large clinical trial specifically devoted to diabetic patients. Drug-eluting stents may represent a major advance in the management of diabetic patients with coronary heart disease in the near future.
Disciplines :
Endocrinology, metabolism & nutrition
Surgery
Author, co-author :
Warzee, Fabian ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Legrand, Victor ;  Centre Hospitalier Universitaire de Liège - CHU > Cardiologie
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
Angioplastie percutanee coronaire chez le patient diabetique. Partie 3: Nouvelles perspectives apportees par les stents enrobes.
Alternative titles :
[en] Percutaneous coronary angioplasty in diabetic patients: new prospects with drug-eluting stents
Publication date :
2004
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
59
Issue :
12
Pages :
711-6
Peer reviewed :
Peer reviewed
Additional URL :
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