ORBi: Debacq Christophe - Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep.

Reference : Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissue...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Oncology Life sciences : Biochemistry, biophysics & molecular biology Life sciences : Agriculture & agronomy
	To cite this reference:	http://hdl.handle.net/2268/21193

Title :	Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep.
Language :	English
Author, co-author :	Debacq, Christophe [Université de Liège - ULG/ FNRS Fusagx > Gembloux Agro-Bio Tech > Biologie Moléculaire et Cellulaire > >]
	Gillet, Nicolas [Université de Liège - ULg > Chimie et bio-industries > Biologie cell. et moléc. >]
	Asquith, Becca [Imperial College, London > Department of immunology > > >]
	Sanchez-Alcaraz, Maria theresa [University of Toronto - U of T > Department of Medical Genetics and Microbiology > > >]
	Florins, Arnaud-Francois [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
	Boxus, Mathieu [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
	Schwartz-Cornil, Isabelle [Institut Scientifique de Recherche Agronomique - INRA, Jouy en Josas > U 892 > > >]
	Bonneau, Michel [Institut Scientifique de Recherche Agronomique - INRA, Jouy-en-josas > U 892 > > >]
	Jean, Geneviève [Université de Liège > > Gembloux Agro-Bio Tech >]
	Kerkhofs, Pierre [Veterinary and Agrochemical research centre, Belgium > Department of Virology > > >]
	Hay, Jack [University of Toronto - U of T > Department of Immunology > > >]
	Thewis, André [Université de Liège > > Gembloux Agro-Bio Tech >]
	Kettmann, Richard [Université de Liège - ULg > Chimie et bio-industries > Biologie cell. et moléc. >]
	Willems, Luc [Université de Liège > > GIGA-Research >]
Publication date :	2006
Journal title :	Journal of Virology
Publisher :	American Society for Microbiology (ASM)
Volume :	80
Issue/season :	19
Pages :	9710-9719
Audience :	International
ISSN :	0022-538X
e-ISSN :	1098-5514
City :	Washington
Country :	DC
Keywords :	[en] B-cell homeostasis ; Bovine Leukemia Virus ; Peripheral blood circulation ; Virology ; Microbiology ; Sheep ; Lymphoid tissues ; Infection ; Deltaretrovirus
	[fr] Homéostasie des cellules B ; Virus de la leucémie bovine ; Circulation sanguine périphérique ; Tissus lymphoïdes ; Infection ; Delta rétrovirus ; Virologie ; Microbiologie ; Mouton
Abstract :	[en] The size of a lymphocyte population is primarily determined by a dynamic equilibrium between cell proliferation and death. Hence, lymphocyte recirculation between the peripheral blood and lymphoid tissues is a key determinant in the maintenance of cell homeostasis. Insights into these mechanisms can be gathered from large-animal models, where lymphatic cannulation from individual lymph nodes is possible. In this study, we assessed in vivo lymphocyte trafficking in bovine leukemia virus (BLV)-infected sheep. With a carboxyfluorescein diacetate succinimidyl ester labeling technique, we demonstrate that the dynamics of lymphocyte recirculation is unaltered but that accelerated proliferation in the lymphoid tissues is compensated for by increased death in the peripheral blood cell population. Lymphocyte homeostasis is thus maintained by biphasic kinetics in two distinct tissues, emphasizing a very dynamic process during BLV infection.
Funders :	Belgian Foundation against the Cancer ; the 6th Framework program INCA project of the European Union ; the Bekales Foundation ; the Fortis Bank Assurance ; Fonds National de la Recherche Scientifique - FNRS ; the Leverhulme Trust ; Interuniversity attraction Poles Programme
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/21193
	also: http://hdl.handle.net/2268/10577 ; http://hdl.handle.net/2268/138831
DOI :	10.1128/JVI.01022-06
Other URL :	http://jvi.asm.org/
Mentions required by the publisher for OA :	Copyright (c) Américan Society for Microbiology

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