Reference : Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissue...
Scientific journals : Article
Human health sciences : Oncology
Life sciences : Biochemistry, biophysics & molecular biology
Life sciences : Agriculture & agronomy
http://hdl.handle.net/2268/21193
Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep.
English
Debacq, Christophe [Université de Liège - ULG/ FNRS Fusagx > Gembloux Agro-Bio Tech > Biologie Moléculaire et Cellulaire > >]
Gillet, Nicolas mailto [Université de Liège - ULg > Chimie et bio-industries > Biologie cell. et moléc. >]
Asquith, Becca mailto [Imperial College, London > Department of immunology > > >]
Sanchez-Alcaraz, Maria theresa [University of Toronto - U of T > Department of Medical Genetics and Microbiology > > >]
Florins, Arnaud-Francois [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Boxus, Mathieu mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Schwartz-Cornil, Isabelle mailto [Institut Scientifique de Recherche Agronomique - INRA, Jouy en Josas > U 892 > > >]
Bonneau, Michel mailto [Institut Scientifique de Recherche Agronomique - INRA, Jouy-en-josas > U 892 > > >]
Jean, Geneviève mailto [Université de Liège > > Gembloux Agro-Bio Tech >]
Kerkhofs, Pierre mailto [Veterinary and Agrochemical research centre, Belgium > Department of Virology > > >]
Hay, Jack [University of Toronto - U of T > Department of Immunology > > >]
Thewis, André mailto [Université de Liège > > Gembloux Agro-Bio Tech >]
Kettmann, Richard mailto [Université de Liège - ULg > Chimie et bio-industries > Biologie cell. et moléc. >]
Willems, Luc mailto [Université de Liège > > GIGA-Research >]
2006
Journal of Virology
American Society for Microbiology (ASM)
80
19
9710-9719
Yes (verified by ORBi)
International
0022-538X
1098-5514
Washington
DC
[en] B-cell homeostasis ; Bovine Leukemia Virus ; Peripheral blood circulation ; Virology ; Microbiology ; Sheep ; Lymphoid tissues ; Infection ; Deltaretrovirus
[fr] Homéostasie des cellules B ; Virus de la leucémie bovine ; Circulation sanguine périphérique ; Tissus lymphoïdes ; Infection ; Delta rétrovirus ; Virologie ; Microbiologie ; Mouton
[en] The size of a lymphocyte population is primarily determined by a dynamic equilibrium between cell proliferation and death. Hence, lymphocyte recirculation between the peripheral blood and lymphoid tissues is a key determinant in the maintenance of cell homeostasis. Insights into these mechanisms can be gathered from large-animal models, where lymphatic cannulation from individual lymph nodes is possible. In this study, we assessed in vivo lymphocyte trafficking in bovine leukemia virus (BLV)-infected sheep. With a carboxyfluorescein diacetate succinimidyl ester labeling technique, we demonstrate that the dynamics of lymphocyte recirculation is unaltered but that accelerated proliferation in the lymphoid tissues is compensated for by increased death in the peripheral blood cell population. Lymphocyte homeostasis is thus maintained by biphasic kinetics in two distinct tissues, emphasizing a very dynamic process during BLV infection.
Belgian Foundation against the Cancer ; the 6th Framework program INCA project of the European Union ; the Bekales Foundation ; the Fortis Bank Assurance ; Fonds National de la Recherche Scientifique - FNRS ; the Leverhulme Trust ; Interuniversity attraction Poles Programme
Researchers
http://hdl.handle.net/2268/21193
also: http://hdl.handle.net/2268/10577 ; http://hdl.handle.net/2268/138831
10.1128/JVI.01022-06
http://jvi.asm.org/
Copyright (c) Américan Society for Microbiology

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