Reference : Even attenuated bovine leukemia virus proviruses can be pathogenic in sheep.
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Human health sciences : Oncology
http://hdl.handle.net/2268/10562
Even attenuated bovine leukemia virus proviruses can be pathogenic in sheep.
English
Florins, Arnaud-Francois [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Gillet, Nicolas [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Boxus, Mathieu mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Kerkhofs, Pierre [> > > >]
Kettmann, Richard mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Willems, Luc mailto [Université de Liège - ULg > > GIGA-Research >]
2007
Journal of virology
81
18
10195-200
Yes
International
0022-538X
United States
[en] Amino Acid Motifs/genetics ; Animals ; Cattle ; Cell Transformation, Viral/genetics ; DNA Mutational Analysis ; Enzootic Bovine Leukosis/genetics/virology ; Leukemia Virus, Bovine/genetics/pathogenicity ; Lymphoma/genetics/veterinary/virology ; Membrane Proteins/genetics ; Sequence Deletion ; Sheep/virology ; Sheep Diseases/genetics/virology ; Time Factors ; Viral Proteins/genetics ; Virus Latency/genetics
[en] Based on a reverse genetics approach, we previously reported that bovine leukemia virus (BLV) mutants harboring deletions in the accessory R3 and G4 genes persist at very low proviral loads and are unable to induce leukemia or lymphoma in sheep, indicating that these R3 and G4 gene sequences are required for pathogenesis. We now show that lymphoma can occur, albeit infrequently (1 case of 20) and after extended periods of latency (7 years). Direct sequencing and reinfection experiments demonstrated that lymphomagenesis was not due to the reversion of the mutant to the wild type. Similar observations with another type of attenuated mutant impaired in the transmembrane protein (TM) YXXL signaling motifs were made. We conclude that the R3 and G4 genes and the TM YXXL motifs are not strictly required for pathogenesis but that their integrity contributes to disease frequency and latency.
http://hdl.handle.net/2268/10562
also: http://hdl.handle.net/2268/32294
10.1128/JVI.01058-07

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