Reference : Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/10555
Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human.
English
Gillet, Nicolas mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Florins, Arnaud-Francois [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Boxus, Mathieu mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Burteau, Catherine [> > > >]
Nigro, Annamaria [> > > >]
Vandermeers, Fabian [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Balon, Herve [> > > >]
Bouzar, Amel [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Defoiche, Julien [> > > >]
Burny, Arsene [> > > >]
Reichert, Michal [> > > >]
Kettmann, Richard mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Willems, Luc mailto [Université de Liège - ULg > > GIGA-Research >]
2007
Retrovirology
BioMed Central
4
1
18
Yes (verified by ORBi)
International
0042-6822
1742-4690
London
United Kingdom
[en] Animals ; Anti-Retroviral Agents/pharmacology/therapeutic use ; B-Lymphocytes/pathology/physiology/virology ; Cattle ; Cytokines/metabolism ; Disease Models, Animal ; Enzootic Bovine Leukosis/drug therapy/physiopathology/virology ; Human T-lymphotropic virus 1/pathogenicity ; Humans ; Leukemia Virus, Bovine/genetics/metabolism/pathogenicity ; Leukemia-Lymphoma, Adult T-Cell/drug therapy/physiopathology ; Leukocytes, Mononuclear/pathology/physiology/virology ; Sheep ; Sheep Diseases/drug therapy/immunology/physiopathology/virology ; Viral Proteins/genetics/metabolism
[en] In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.
http://hdl.handle.net/2268/10555
also: http://hdl.handle.net/2268/32022
10.1186/1742-4690-4-18

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