Article (Scientific journals)
Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human.
Gillet, Nicolas; Florins, Arnaud-Francois; Boxus, Mathieu et al.
2007In Retrovirology, 4 (1), p. 18
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Keywords :
Animals; Anti-Retroviral Agents/pharmacology/therapeutic use; B-Lymphocytes/pathology/physiology/virology; Cattle; Cytokines/metabolism; Disease Models, Animal; Enzootic Bovine Leukosis/drug therapy/physiopathology/virology; Human T-lymphotropic virus 1/pathogenicity; Humans; Leukemia Virus, Bovine/genetics/metabolism/pathogenicity; Leukemia-Lymphoma, Adult T-Cell/drug therapy/physiopathology; Leukocytes, Mononuclear/pathology/physiology/virology; Sheep; Sheep Diseases/drug therapy/immunology/physiopathology/virology; Viral Proteins/genetics/metabolism
Abstract :
[en] In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Gillet, Nicolas ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Florins, Arnaud-Francois ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Boxus, Mathieu ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Burteau, Catherine
Nigro, Annamaria
Vandermeers, Fabian ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Balon, Herve
Bouzar, Amel ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Defoiche, Julien
Burny, Arsène ;  Université de Liège - ULiège > Agro Biotech Gembloux
Reichert, Michal
Kettmann, Richard ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Willems, Luc  ;  Université de Liège - ULiège > GIGA-Research
More authors (3 more) Less
Language :
English
Title :
Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human.
Publication date :
2007
Journal title :
Retrovirology
eISSN :
1742-4690
Publisher :
BioMed Central, London, United Kingdom
Volume :
4
Issue :
1
Pages :
18
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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