Characterisation of pregnancy losses after embryo transfer by measuring plasma progesterone and bovine pregnancy-associated glycoprotein-1 concentrations
Breukelman, S. P.; Perényi, Z.; Taverne, M. A. M.et al.
[en] The aim of this analysis was to determine whether pregnancy loss (PL) after embryo transfer (ET) in cattle was related to maternal progesterone (P4) concentrations during and shortly after ET, and maternal bovine pregnancy-associated glycoprotein-1 (bPAG-1) concentrations in plasma at days 25–35 of gestation. Embryos (n = 260) were produced either in vivo after superovulation (n = 115), or in vitro from oocytes (obtained with ovum pick-up) in co-culture (n = 44) or cultured in a synthetic medium (n = 101). Overall, PL was 56.9% (148) and no significant differences occurred in calving rate among the three embryo production groups. There was no difference in P4 concentrations on days 7–14 of gestation in the three groups, nor between ongoing and interrupted pregnancies. Between days 25 and 35 of pregnancy, bPAG-1 concentrations were unaffected by embryo production, but in cattle that had PL between days 26 and 120, four bPAG-1 profiles could be detected. Between days 25 and 32, bPAG-1 concentrations were influenced by PL, and concentrations were significantly lower in animals in which PL occurred between days 26 and 120 than in those animals that aborted later or calved at term. Early P4 concentrations suggested that maternal luteal factors were not responsible for PL which appeared to be caused by impaired conceptus development (regardless of embryo type) as reflected by low maternal bPAG-1 concentrations prior to embryonic death
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Breukelman, S. P.
Perényi, Z.
Taverne, M. A. M.
Jonker, H.
Van der Weijden, G. C.
Vos, P. L.A.M
de Ruigh, L.
Dieleman, S. J.
Beckers, Jean-François ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Szenci, O.
Language :
English
Title :
Characterisation of pregnancy losses after embryo transfer by measuring plasma progesterone and bovine pregnancy-associated glycoprotein-1 concentrations
Publication date :
October 2012
Journal title :
Veterinary Record
ISSN :
0042-4900
eISSN :
2042-7670
Publisher :
British Veterinary Medicine, London, United Kingdom
Breukelman S.P., Reinders J.M.C., Jonker F.H., de Ruigh L., Kaal L.M.T.E., van Wagtendonk-de Leeuw A.M., Vos P.L.A.M., Dieleman S.J., Beckers J.F., Perényi Zs., Taverne M.A.M. Fetometry and fetal heart rates between day 35 and 108 in bovine pregnancies resulting from transfer of either MOET, IVP-co-culture, or IVP-SOF. Theriogenology 2004, 61:867-882.
Breukelman S.P., Perényi Zs., de Ruigh L., van Wagtendonk-de Leeuw A.M., Jonker F.H., Vernooij J.C.M., Beckers J.F., van der Weijden G.C., Vos P.L.A.M., Dieleman S.J., Taverne M.A.M. Plasma concentrations of bovine pregnancy-associated glycoprotein (bPAG) do not differ during the first 119 days between ongoing pregnancies derived by transfer of in vivo and in vitro produced embryos. Theriogenology 2005, 63:1378-1389.
Breukelman S.P., Szenci O., Beckers J.F., Kindahl H., Mulder E.J.H., Jonker F.H., van der Weijden G.C., Révy D., Pogány K., Sulon J., Némedi I., Taverne M.A.M. Ultrasonographic appearance of the conceptus, fetal heart rate and profiles of pregnancy-associated glycoproteins (PAG) and prostaglandin F2α-metabolite (PGF2α-metabolite) after induction of fetal death with aglepristone during early gestation in cattle. Theriogenology 2005, 64:917-933.
Chagas e Silva J., Lopes da Costa L., Robalo Silva J. Plasma progesterone profiles and factors affecting embryo-fetal mortality following embryo transfer in dairy cattle. Theriogenology 2002, 58:51-59.
Chavatte-Palmer P., Heyman Y., Richard C., Monget P., LeBourhis D., Kann G., Chilliard Y., Vignon X., Renard J.P. Clinical, hormonal, and hematological characteristics of bovine calves derived from nuclei from somatic cells. Biology of Reproduction 2002, 66:1596-1603.
Chavatte-Palmer P., de Sousa N., Laigre P., Camous S., Ponter A.A., Beckers J.F., Heyman Y. Ultrasound fetal measurements and pregnancy associated glycoprotein secretion in early pregnancy in cattle recipients carrying somatic clones. Theriogenology 2006, 66:829-840.
Dieleman S.J., Bevers M.M. Effects of monoclonal antibody against PMSG administered shortly after the preovulatory LH surge on time and number of ovulations in PMSG/PG-treated cows. Journal of Reproduction and Fertility 1987, 81:533-542.
Ectors F.J., Schmidt M., Smith L.C., Sulon J., Delval A., Remy B., Avery B., Beckers J.F. PAG profiles in recipient heifers after transfer of IVF and nuclear transfer embryos. Theriogenology 1996, 45:283. (Abstract).
Heyman Y., Chavatte-Palmer P., LeBourhis D., Camous S., Vignon X., Renard J.P. Frequency and occurrence of late-gestation losses from cattle cloned embryos. Biology of Reproduction 2002, 66:6-13.
Hill J.R., Burghardt R.C., Jones K., Long C.R., Looney C.R., Shin T., Spencer T.E., Thompson J.A., Winger Q.A., Westhusin M.E. Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses. Biology of Reproduction 2000, 63:1787-1794.
Humblot P., Camous S., Martal J., Charlery J., Jeanguyot N., Thibier M., Sasser R.G. Pregnancy-specific protein B, progesterone concentrations and embryonic mortality during early pregnancy in dairy cows. Journal of Reproduction and Fertility 1988, 83:215-223.
López-Gatius F., Hunter R.H., Garbayo J.M., Santolaria P., Yániz J., Serrano B., Ayad A., de Sousa N.M., Beckers J.F. Plasma concentrations of pregnancy-associated glycoprotein-1 (PAG-1) in high producing dairy cows suffering early fetal loss during the warm season. Theriogenology 2007, 67:1324-1330.
Kruip T.A.M., den Daas J.H.G. In vitro produced and cloned embryos: Effects on pregnancy, parturition and offspring. Theriogenology 1997, 47:43-52.
Lenton E.A., Osborn J., Colman C., Fothergill D. Premenstrual pregnancy loss: A significant contribution to the low pregnancy rates following in vitro fertilization. Annals of the New York Academy of Sciences 1988, 541:498-509.
Liu H.C., Rosenwaks Z. Early pregnancy wastage in IVF (in vitro fertilization) patients. Journal of In Vitro Fertilization and Embryo Transfer 1991, 8:65-72.
López-Gatius F., Garcia-Inspirito I. Ultrasound and endocrine findings that help to assess the risk of late embryo/early fetal loss by non-infectious cause in dairy cattle. Reproduction in Domestic Animals 2010, 45:15-24.
Macklon N.S., Geraedts J.P.M., Fauser B.C.J.M. Conception to ongoing pregnancy: The black box of early pregnancy loss. Human Reproduction Update 2002, 8:333-343.
Mialon M.M., Camous S., Renand G., Martal J., Menissier F. Peripheral concentrations of a 60-kDa pregnancy serum protein during gestation and after calving and in relationship to embryonic mortality in cattle. Reproduction Nutrition Development 1993, 33:269-282.
Niemann H., Sacher B., Elsaesser F. Pregnancy rates relative to recipient plasma progesterone concentrations on the day of nonsurgical transfer of frozen/thawed bovine embryos. Theriogenology 1985, 23:631-639.
Northey D.L., Barnes F.L., Eyestone W.H., First N.L. Relationship of serum progesterone, luteinizing hormone and the incidence of pregnancy in bovine embryo transfer recipients. Theriogenology 1985, 23:214. (Abstract).
Perényi Zs., Szenci O., Sulon J., Drion P.V., Beckers J.F. Comparison of the ability of three radioimmunoassays to detect pregnancy-associated glycoproteins in bovine plasma. Reproduction in Domestic Animals 2002, 37:100-104.
Peterson, A.J., McMillan, W.H., 1998. Allantoic aplasia - A consequence of in vitro production of bovine embryos and the major cause of late gestation embryo loss. In: Proceedings of the 29th Annual Conference of the Australian Society for Reproductive Biology, Perth, Australia (Abstract 4).
Peterson, A.J., McMillan, W.H., 1998. Variation in the rate of emergence of the bovine allantois. In: Proceedings of the 29th Annual Conference of the Australian Society for Reproductive Biology, Perth, Australia (Abstract 63).
Pieterse M.C., Szenci O., Willemse A.H., Bajcsy Cs.á., Dieleman S.J., Taverne M.A.M. Early pregnancy diagnosis in cattle by means of linear-array real-time ultrasound scanning of the uterus and a qualitative and quantitative milk progesterone test. Theriogenology 1990, 33:697-708.
Remsen L.G., Roussel J.D., Karihaloo A.K. Pregnancy rates relating to plasma progesterone concentrations in recipient heifers at day of transfer. Theriogenology 1982, 17:105. (Abstract).
Semambo D.K.N., Eckersall P.D., Sasser R.G., Ayliffe T.R. Pregnancy-specific protein B and progesterone in monitoring viability of the embryo in early pregnancy in the cow after experimental infection with Actinomyces pyogenes. Theriogenology 1992, 37:741-748.
Serrano B., López-Gatius F., Hunter R.H.F., Santolaria P., García-Ispierto I., Bech-Sabat G., De Sousa N.M., Beckers J.F., Yániz J.L. Anomalous pregnancies during late embryonic/early fetal period in high producing dairy cows. Reproduction in Domestic Animals 2009, 44:672-676.
Smith A.K., Broadbent P.J., Dolman D.F., Grimmer S.P., Davies D.A., Dobson H. Norgestomet implants, plasma progesterone concentrations and embryo transfer pregnancy rates in cattle. Veterinary Record 1996, 139:187-191.
Spell A.R., Beal W.E., Corah L.R., Lamb G.C. Evaluating recipient and embryo factors that affect pregnancy rates of embryo transfer in beef cattle. Theriogenology 2001, 56:287-297.
Manual of the International Embryo Transfer Society 1998, International Embryo Transfer Society, Savoy, Illinois, USA. Third Ed. D.A. Stringfellow, S.M. Seidel (Eds.).
Stubbings R.B., Walton J.S. Relationship between plasma progesterone concentrations and pregnancy rates in cattle receiving either fresh or previously frozen embryos. Theriogenology 1986, 26:145-155.
Szenci O., Humblot P., Beckers J.F., Sulon J., Baltusen R., Varga J., Bajcsy Cs.á., Taverne M.A.M. Plasma profiles of progesterone and conceptus proteins in cows with spontaneous embryonic/fetal mortality as diagnosed by ultrasonography. The Veterinary Journal 2000, 159:287-290.
Szenci O., Beckers J.F., Sulon J., Bevers M.M., Börzsönyi L., Fodor L., Kovács F., Taverne M.A.M. Effect of induction of late embryonic mortality on plasma profiles of pregnancy associated glycoprotein 1 in heifers. The Veterinary Journal 2003, 165:307-313.
van Wagtendonk-de Leeuw A.M., Mullaart E., de Roos A.P., Merton J.S., den Daas J.H., Kemp B., de Ruigh L. Effects of different reproduction techniques: AI, MOET, or IVP, on health and welfare of bovine offspring. Theriogenology 2000, 53:575-597.
Vanroose G., de Kruif A., Van Soom A. Embryonic mortality and embryo-pathogen interactions. Animal Reproduction Science 2000, 60-61:131-143.
Zoli A.P., Beckers J.F., Wouters-Ballman P., Closset J., Falmagne P., Ectors F. Purification and characterization of a bovine pregnancy-associated glycoprotein. Biology of Reproduction 1991, 45:1-10.
Zoli A.P., Guilbault L.A., Delahaut P., Ortiz W.B., Beckers J.F. Radioimmunoassay of a bovine pregnancy-associated glycoprotein in serum: Its application for pregnancy diagnosis. Biology of Reproduction 1992, 46:83-92.